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dc.contributor.advisor陈小芬
dc.contributor.author牟鹏飞
dc.date.accessioned2016-02-23T01:32:14Z
dc.date.available2016-02-23T01:32:14Z
dc.date.issued2015-04-16 10:11:28.0
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/97723
dc.description.abstract作为衰老过程中一个重要的特点,神经炎症与多种神经退行性疾病密切相关,特别是老年痴呆症(Alzheimer’sDisease,AD)。TREM2(Triggeringreceptorexpressedonmyeloidcells2)是最近通过全基因组关联研究(Genome-WideAssociationStudies,GWAS)鉴定出的AD风险基因。研究表明:TREM2在脑内主要参与小胶质细胞对凋亡神经元等的内吞作用,同时抑制脑内炎症反应的扩大。大量的人群基因测序显示TREM2基因突变与多种神经退行性疾病存在相关性,提示可能是TREM2功能异常导致脑内炎症稳态失调,进而引起神经退行性疾病的发生。...
dc.description.abstractAs a major characteristic of the aging process, neuroinflammation is involved in the pathogenesis of several aging-related diseases including Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells 2 (TREM2) is a newly identified risk gene for AD. TREM2, as an innate immune receptor expressed on the cell membrane, is mainly expressed in immature dendritic cells, osteoclasts, tissu...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=45453&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=46115
dc.subjectTREM2
dc.subject
dc.subject转录调控
dc.subjectNF-κB
dc.subject细菌脂多糖
dc.subjectTREM2
dc.subject
dc.subjectTranscriptional regulation
dc.subjectNF-κB
dc.subjectLPS
dc.title与老年性痴呆相关基因TREM2的转录调控研究
dc.title.alternativeTranscriptional Regulation of TREM2 in Alzheimer’s Disease
dc.typethesis
dc.date.replied2014-05-15
dc.description.note学位:理学硕士
dc.description.note院系专业:医学院基础医学系_微生物学
dc.description.note学号:21620111152404


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