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dc.contributor.advisor陈瑞川
dc.contributor.author周超
dc.date.accessioned2016-02-23T01:25:47Z
dc.date.available2016-02-23T01:25:47Z
dc.date.issued2015-04-16 14:58:04.0
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/97111
dc.description.abstractP-TEFb复合体是调控真核基因转录延伸的重要转录因子。P-TEFb以两种形式存在于细胞内,第一种形式是与7SK和HEXIM1形成无活性7SKsnRNP复合体;另一种形式是有转录活性的复合体。P-TEFb与BRD4结合,形成BRD4-PTEFb是最早发现的活性复合物。最近研究发现P-TEFb也与ELL2和AFF4形成新型活性复合物,也就是超级延伸复合物(简称SECs),这类复合物还包含ENL、AF9、AFF1等因子[1-4]。鉴于P-TEFb和SECs在转录延伸过程中的重要作用,本实验室前期已对P-TEFb无活性复合体(7SKsnRNP)与活性复合体(BRD4/P-TEFb,SECs)如何相互...
dc.description.abstractP-TEFb is a critical elongation factor for the control of transcription elongation in eukaryotes. There are two forms of P-TEFb in cells. The first form is inactive 7SK snRNP complex containing other factors such as 7SK and HEXIM1. The second form is a transcriptionally active complex. The first discovered active complex is formed by P-TEFb and BRD4. Recent studies have identified another transcri...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=45584&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=44552
dc.subjectP-TEFb
dc.subjectSECs
dc.subjectNuclear speckles
dc.subjectP-TEFb
dc.subjectSECs
dc.subjectNuclear speckles
dc.titleP-TEFb 活性复合物组装的细胞定位研究
dc.title.alternativeCellular localization of the assembly of P-TEFb active complexes
dc.typethesis
dc.date.replied2014-05-17
dc.description.note学位:理学硕士
dc.description.note院系专业:生命科学学院_生物化学与分子生物学
dc.description.note学号:21620111152499


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