Syntheses, characterizations, and crystal structures of phosphonopeptides
- 化学化工－已发表论文 
alpha-Aminophosphonic acids and their derivatives, as phosphorus analogs of amino acids, have attracted much attention as they show a range of biological activities. In this paper, dialkyl phenyl(4-pyridylcarbonylamino)methylphosphonates were synthesized via the Mannich reaction (Yuan et al., Synthesis 1990, 3, 256) and peptide coupling. Their structures were confirmed by elemental analysis, IR, H-1 NMR, C-13 NMR, and MS. X-ray diffraction data of compounds (2a, 2b, 2c) were reported respectively. The antibacterial and antitumor activities of these compounds are first reported in this paper. (c) 2007 Wiley Periodicals, Inc.