Antityrosinase and antimicrobial activities of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid
Zhu, Yu-Jing（Fujian Acad Agr Sci, Agr Bioresources Inst）
Tang, Jian-Yang（Fujian Acad Agr Sci, Agr Bioresources Inst）
Su, Ming-Xing（Fujian Acad Agr Sci, Agr Bioresources Inst）
Liu, Bo（Fujian Acad Agr Sci, Agr Bioresources Inst）
- 生命科学－已发表论文 
The inhibition kinetics of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid on the enzyme activity of mushroom tyrosinase have been investigated. The results showed that these aromatic compounds can lead to reversible inhibition of the enzyme; furthermore, 2-phenylacetaldehyde and 2-phenylacetic acid are uncompetitive inhibitors and 2-phenylethanol is a mixed-type inhibitor. The inhibition constants have been determined and the inhibiting ability was: 2-phenylacetaldehyde > 2-phenylacetic acid > 2-phenylethanol, indicating that the functional group on the benzene ring group played an important role in the inhibition of the enzyme. In addition, 2-phenylacetic acid and 2-phenylethanol were found to have effective antibacterial activities, and 2-phenylacetic acid was more effective against Escherichia coli and Ralstonia solanacearum than 2-phenylethanol, but 2-phenylacetaldehyde lacked of antibacterial activity. (C) 2010 Elsevier Ltd. All rights reserved.