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dc.contributor.authorZhang Hong-Kui
dc.contributor.author张洪奎
dc.contributor.authorChen Wei-Qiang
dc.contributor.author陈伟强
dc.date.accessioned2011-06-12T03:32:37Z
dc.date.available2011-06-12T03:32:37Z
dc.date.issued2007
dc.identifier.citationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(4):684-691zh_CN
dc.identifier.issn0251-0790
dc.identifier.urihttp://dx.doi.org/doi:CNKI:ISSN:0251-0790.0.2007-04-023
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/9477
dc.description.abstractAigialomycin D( 1 ) possesses a potent antitumor activity and anti-malarial activity. In this paper a concise route for the synthesis of the key C2'-C7' fragment of aigialomycin D by using D-( - ) -ribose was described. The fragment was synthesized in six steps in 37. 2% overall yield, including protection of the vicinal diol, Wittig reaction of the lactol, hydrogenation, oxidative cleavage of the diol, terminal olefination and selective reduction of the ester. This work lays a good foundation for the total synthesis of aigialomycin D.zh_CN
dc.language.isozhzh_CN
dc.publisherHIGHER EDUCATION PRESSzh_CN
dc.subjectaigialomycin Dzh_CN
dc.subjectD-(-)-ribosezh_CN
dc.subjectsynthesiszh_CN
dc.titleA concise synthesis of C2 '-C7 ' fragment of aigialomycin Dzh_CN
dc.typeArticlezh_CN


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