A concise synthesis of C2 '-C7 ' fragment of aigialomycin D

Abstract

Aigialomycin D( 1 ) possesses a potent antitumor activity and anti-malarial activity. In this paper a concise route for the synthesis of the key C2'-C7' fragment of aigialomycin D by using D-( - ) -ribose was described. The fragment was synthesized in six steps in 37. 2% overall yield, including protection of the vicinal diol, Wittig reaction of the lactol, hydrogenation, oxidative cleavage of the diol, terminal olefination and selective reduction of the ester. This work lays a good foundation for the total synthesis of aigialomycin D.