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A concise synthesis of C2 '-C7 ' fragment of aigialomycin D

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由D_核糖合成AigialomycinDC2_C7_片段的简捷方法.pdf (138.8Kb)
Date
2007
Author
Zhang Hong-Kui
张洪奎
Chen Wei-Qiang
陈伟强
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  • 化学化工-已发表论文 [14469]
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Abstract
Aigialomycin D( 1 ) possesses a potent antitumor activity and anti-malarial activity. In this paper a concise route for the synthesis of the key C2'-C7' fragment of aigialomycin D by using D-( - ) -ribose was described. The fragment was synthesized in six steps in 37. 2% overall yield, including protection of the vicinal diol, Wittig reaction of the lactol, hydrogenation, oxidative cleavage of the diol, terminal olefination and selective reduction of the ester. This work lays a good foundation for the total synthesis of aigialomycin D.
Citation
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(4):684-691
URI
http://dx.doi.org/doi:CNKI:ISSN:0251-0790.0.2007-04-023
https://dspace.xmu.edu.cn/handle/2288/9477

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