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dc.contributor.authorZhao, Zhenghuanzh_CN
dc.contributor.authorHuang, Dengtongzh_CN
dc.contributor.authorYin, Zhenyuzh_CN
dc.contributor.authorChi, Xiaoqinzh_CN
dc.contributor.authorWang, Xiaominzh_CN
dc.contributor.authorGao, Jinhaozh_CN
dc.contributor.author尹震宇zh_CN
dc.contributor.author池小琴zh_CN
dc.contributor.author王效民zh_CN
dc.contributor.author高锦豪zh_CN
dc.date.accessioned2015-07-22T07:37:29Z
dc.date.available2015-07-22T07:37:29Z
dc.date.issued2012 August 21zh_CN
dc.identifier.citationJournal of Materials Chemistry, 2012,22(31):15717-15725zh_CN
dc.identifier.other20123015273412zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93721
dc.description.abstractWe described the smart and targeted magnetic nanocarriers to control the delivery and release of anticancer drug doxorubicin (DOX) in vitro and demonstrated that they can exhibit much higher cytotoxicity to cancer cells than free DOX. The conjugation of targeted magnetite nanoparticles (鈭?4 nm in diameter) and DOX molecule via acid-labile imine bond endows the nanocarriers with three advanced features: magnetically controllable, specific targeting, and pH-responsive. The cell toxicity assays indicated the pH-sensitive magnetic nanocarriers (IC50 of 0.13 渭g mL-1 to HeLa cells) have much higher anticancer activity than free DOX (IC50 of 1.16 渭g mL-1 to HeLa cells). Moreover, the magnetically guided delivery of nanocarriers can further improve the drug efficacy (IC50 of 鈭?.087 渭g mL-1 to HeLa cells). The arginine-glycine-aspartic acid (RGD)-modified magnetic nanocarriers recognized the specific cells effectively (IC50 of 0.93 渭g mL-1 to U-87 MG cells) and showed the increased cytotoxicity to cancer cells under external magnetic fields. This intelligent (magnetically guided, molecular targeted, and pH-responsive) drug delivery system has the ability to improve the chemotherapeutic efficacy and reduce the side effects, which has a great potential to become a favorable strategy for delivery of drugs to the desired sites in patients. 漏 2012 The Royal Society of Chemistry.zh_CN
dc.language.isoen_USzh_CN
dc.publisherRoyal Society of Chemistryzh_CN
dc.source.urihttp://dx.doi.org/10.1039/c2jm31692gzh_CN
dc.subjectAmino acidszh_CN
dc.subjectDrug deliveryzh_CN
dc.subjectDrug interactionszh_CN
dc.subjectMagnetite nanoparticleszh_CN
dc.titleMagnetite nanoparticles as smart carriers to manipulate the cytotoxicity of anticancer drugs: Magnetic control and pH-responsive releasezh_CN
dc.typeArticlezh_CN


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