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dc.contributor.authorJiang, Shangtongzh_CN
dc.contributor.authorLi, Yanfangzh_CN
dc.contributor.authorZhang, Cuilinzh_CN
dc.contributor.authorZhao, Yingjunzh_CN
dc.contributor.authorBu, Guojunzh_CN
dc.contributor.authorXu, Huaxizh_CN
dc.contributor.authorZhang, Yun-Wuzh_CN
dc.contributor.author李艳芳zh_CN
dc.contributor.author卜国军zh_CN
dc.contributor.author许华曦zh_CN
dc.contributor.author张云武zh_CN
dc.date.accessioned2015-07-22T07:37:21Z
dc.date.available2015-07-22T07:37:21Z
dc.date.issued2014 APRzh_CN
dc.identifier.citationNEUROSCIENCE BULLETIN, 2014,30(2):295-307zh_CN
dc.identifier.otherWOS:000334513200013zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93641
dc.descriptionNational Institutes of Health, USA [R01AG038710, R01AG021173, R01AG044420, R01NS046673]; Alzheimer's Association; National Natural Science Foundation of China [91332112, 81225008, 81161120496]; Fundamental Research Funds for the Central Universities of China; Fok Ying Tung Education Foundationzh_CN
dc.description.abstractThe degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment.zh_CN
dc.language.isoen_USzh_CN
dc.publisherSPRINGERzh_CN
dc.source.urihttp://dx.doi.org/10.1007/s12264-013-1406-zzh_CN
dc.subjectAMYLOID PRECURSOR PROTEINzh_CN
dc.subjectAFFINITY AGONIST BINDINGzh_CN
dc.subjectKNOCKOUT MICEzh_CN
dc.subjectCEREBRAL-CORTEXzh_CN
dc.subjectMUTANT MICEzh_CN
dc.subjectKINASE-Czh_CN
dc.subjectIN-VIVOzh_CN
dc.subjectCHOLINERGIC MODULATIONzh_CN
dc.subjectXANOMELINE IMPROVESzh_CN
dc.subjectTAU PHOSPHORYLATIONzh_CN
dc.titleM1 muscarinic acetylcholine receptor in Alzheimer's diseasezh_CN
dc.typeArticlezh_CN


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