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dc.contributor.authorLin, Chan-Chanzh_CN
dc.contributor.authorZhou, Jing-Pingzh_CN
dc.contributor.authorLiu, Yun-Pengzh_CN
dc.contributor.authorLiu, Jing-Jingzh_CN
dc.contributor.authorYang, Xiao-Ningzh_CN
dc.contributor.authorJazag, Amarsanaazh_CN
dc.contributor.authorZhang, Zhi-Pingzh_CN
dc.contributor.authorGuleng, Bayasizh_CN
dc.contributor.authorRen, Jian-Linzh_CN
dc.contributor.author任建林zh_CN
dc.date.accessioned2015-07-22T07:36:47Z
dc.date.available2015-07-22T07:36:47Z
dc.date.issued2012-12-26zh_CN
dc.identifier.citationPLOS ONE, 2012,7(12)zh_CN
dc.identifier.otherWOS:000313618800037zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93329
dc.descriptionYouth Innovation Fund of Fujian Province [2006F3127]; National Natural Science Foundation of China [30971362, 81072013]; Fundamental Research Funds for the Central Universities in China [2010111082]zh_CN
dc.description.abstractPokemon (POK erythroid myeloid ontogenic factor), which belongs to the POK protein family, is also called LRF, OCZF and FBI-1. As a transcriptional repressor, Pokemon assumes a critical function in cellular differentiation and oncogenesis. Our study identified an oncogenic role for Pokemon in human hepatocellular carcinoma (HCC). We successfully established human HepG2 and Huh-7 cell lines in which Pokemon was stably knocked down. We demonstrated that Pokemon silencing inhibited cell proliferation and migration. Pokemon knockdown inhibited the PI3K/Akt and c-Raf/MEK/ERK pathways and modulated the expression of various cell cycle regulators in HepG2 and Huh-7 cells. Therefore, Pokemon may also be involved in cell cycle progression in these cells. We confirmed that Pokemon silencing suppresses hepatocellular carcinoma growth in tumor xenograft mice. These results suggest that Pokemon promotes cell proliferation and migration in hepatocellular carcinoma and accelerates tumor development in an Akt- and ERK-signaling-dependent manner.zh_CN
dc.language.isoen_USzh_CN
dc.publisherPLOS ONEzh_CN
dc.source.urihttp://dx.doi.org/10.1371/journal.pone.0051916zh_CN
dc.subjectREPRESSES TRANSCRIPTIONzh_CN
dc.subjectNUCLEAR-LOCALIZATIONzh_CN
dc.subjectTUMOR SUPPRESSIONzh_CN
dc.subjectPOOR-PROGNOSISzh_CN
dc.subjectFBI-1zh_CN
dc.subjectACTIVATIONzh_CN
dc.subjectGENEzh_CN
dc.subjectEXPRESSIONzh_CN
dc.subjectPROTEINzh_CN
dc.subjectGROWTHzh_CN
dc.titleThe Silencing of Pokemon Attenuates the Proliferation of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Inhibiting the PI3K/Akt Pathwayzh_CN
dc.typeArticlezh_CN


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