Show simple item record

dc.contributor.authorLiu, Ying-Fuzh_CN
dc.contributor.authorZhang, Peng-Feizh_CN
dc.contributor.authorLi, Mao-Yuzh_CN
dc.contributor.authorLi, Quo-Qingzh_CN
dc.contributor.authorChen, Zhu-Chuzh_CN
dc.contributor.author刘迎福zh_CN
dc.date.accessioned2015-07-22T07:36:44Z
dc.date.available2015-07-22T07:36:44Z
dc.date.issued2011-06zh_CN
dc.identifier.citationCLINICAL & EXPERIMENTAL METASTASIS, 2011,28(5):413-425zh_CN
dc.identifier.otherWOS:000289797600001zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93296
dc.descriptionNational Key Basic Research Program of China [2001CB510207]; Fundamental Research Funds for the Central Universities [2010 121104]; Ministry of Education of China [2002-48]zh_CN
dc.description.abstractMetastasis is the most common cause of death in lung cancer patients and is a major obstacle to the successful treatment. To discover novel metastasis-related proteins in lung adenorcinoma (AdC), quantitative proteomic analysis was performed between primary lung AdC tissues with (LNM AdC) and without lymph node metastasis (non-LNM AdC). In this study, annexin A1 was identified to be significantly up-regulated in LNM AdC compared with non-LNM AdC. Immunohistochemistry showed that annexin A1 over-expression was frequently observed in LNM AdCs and matched lymph node metastases compared with non-LNM AdCs. Annexin A1 over-expression was significantly associated with advanced clinical stage (P < 0.05) and lymph node metastasis (P < 0.05) and increased relapse rate (P < 0.05) and decreased overall survival (P < 0.05) in lung AdCs. Cox regression analysis indicated annexin A1 over-expression was an independent prognostic factor. Furthermore, suppression of annexin A1 expression by siRNA interference significantly inhibited the invasion ability of lung adenocarcinoma cell A549 in vitro. In conclusion, annexin A1 expression correlated with tumor stage, lymph node metastasis, relapse, and patient survival. Annexin A1 is proposed to function importantly in the progression of lung AdC.zh_CN
dc.language.isoen_USzh_CN
dc.publisherCLIN EXP METASTASzh_CN
dc.source.urihttp://dx.doi.org/10.1007/s10585-011-9380-1zh_CN
dc.subjectDIFFERENCE GEL-ELECTROPHORESISzh_CN
dc.subjectCALCIUM-BINDING PROTEINSzh_CN
dc.subjectPROTEOMIC ANALYSISzh_CN
dc.subjectCOLORECTAL-CARCINOMAzh_CN
dc.subjectCANCERzh_CN
dc.subjectMETASTASISzh_CN
dc.subjectTUMORzh_CN
dc.subjectEXPRESSIONzh_CN
dc.subjectINVASIONzh_CN
dc.subjectMARKERzh_CN
dc.titleIdentification of annexin A1 as a proinvasive and prognostic factor for lung adenocarcinomazh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record