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dc.contributor.authorZhang, Xiao-Fengzh_CN
dc.contributor.authorLai, Eric C. H.zh_CN
dc.contributor.authorKang, Xiao-Yanzh_CN
dc.contributor.authorQian, Hai-Huazh_CN
dc.contributor.authorZhou, Yan-Mingzh_CN
dc.contributor.authorShi, Le-Huazh_CN
dc.contributor.authorShen, Fengzh_CN
dc.contributor.authorYang, Ye-Fazh_CN
dc.contributor.authorZhang, Yuzh_CN
dc.contributor.authorLau, Wan Yeezh_CN
dc.contributor.authorWu, Meng-Chaozh_CN
dc.contributor.authorYin, Zheng-Fengzh_CN
dc.contributor.author周彦明zh_CN
dc.date.accessioned2015-07-22T07:36:43Z
dc.date.available2015-07-22T07:36:43Z
dc.date.issued2011-08zh_CN
dc.identifier.citationANNALS OF SURGICAL ONCOLOGY, 2011,18(8):2218-2223zh_CN
dc.identifier.otherWOS:000292781200017zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93284
dc.descriptionNational High Technology Research and Development Program of China [2007AA02Z461]; China National Key Projects for Infectious Disease [2008ZX10002-021]; National Natural Science Foundation of China [30772513]zh_CN
dc.description.abstractThe aim of this study was to determine the role of Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) as a prognostic marker and a monitor marker of recurrence after curative resection of hepatocellular carcinoma (HCC). From December 2002 to May 2004, 395 consecutive patients with HCC who underwent curative partial hepatectomy were included in the study. The tumor characteristics and clinical outcomes of patients with positive preoperative and postoperative AFP-L3 were compared with those with negative results. A high ratio of AFP-L3 to total AFP was an indicator of pathologic aggressiveness. Patients with positive preoperative AFP-L3 had significantly earlier recurrence (median time to recurrence 22.0 +/- A 2.4 months vs 45.0 +/- A 6.9 months, P < .001) when compared with those with negative preoperative results. Significantly more patients with continuously positive or negative-turn-positive AFP-L3 results after surgery developed recurrence, particularly distant metastases, when compared with patients with continuously negative AFP-L3 results. The overall and disease-free survivals were significantly shorter in the positive than the negative preoperative AFP-L3 group. The overall and disease-free survivals were significantly shorter in the continuously positive and the negative-turn-positive than the continuously negative postoperative AFP-L3 group. Positive preoperative AFP-L3 and continuously positive or negative-turn-positive AFP-L3 results after surgery predicted a more aggressive tumor behavior, higher tumor recurrence, and poorer clinical outcomes. HCC patients with an increased proportion of AFP-L3 to total AFP should be more aggressively treated and closely followed-up.zh_CN
dc.language.isoen_USzh_CN
dc.publisherANN SURG ONCOLzh_CN
dc.source.urihttp://dx.doi.org/10.1245/s10434-011-1613-7zh_CN
dc.subjectCIRRHOTIC-PATIENTSzh_CN
dc.subjectMANAGEMENTzh_CN
dc.subjectHEPATITISzh_CN
dc.subjectABLATIONzh_CN
dc.subjectAFP-L3zh_CN
dc.titleLens Culinaris Agglutinin-Reactive Fraction of Alpha-Fetoprotein as a Marker of Prognosis and a Monitor of Recurrence of Hepatocellular Carcinoma After Curative Liver Resectionzh_CN
dc.typeArticlezh_CN


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