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dc.contributor.authorLiu, Peizh_CN
dc.contributor.authorGuo, Jianlizh_CN
dc.contributor.authorQi, Zhizh_CN
dc.contributor.author戚智zh_CN
dc.date.accessioned2015-07-22T07:36:38Z
dc.date.available2015-07-22T07:36:38Z
dc.date.issued2011-09zh_CN
dc.identifier.citationCANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2011,89(11):837-844zh_CN
dc.identifier.otherWOS:000298016000008zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93245
dc.descriptionNational Basic Research Program of China [2005CB522804]; National Science Foundation of China [31070741]zh_CN
dc.description.abstractFormaldehyde (FA) is widely present in the environment, and is also a mammalian metabolite. However, its biological role has not been well understood. Here, we show that FA plays an anti-apoptotic role in cultured hippocampal neurons: FA suppressed staurosporine-induced neuronal apoptosis and inhibited the activity of apoptosis-associated caspase-3/7 proteases in a concentration-dependent manner. Moreover, FA suppressed outward K+ currents and attenuated the enhanced I-K currents that are associated with neuronal apoptosis. As an increase in outward K+ currents is critical for cell apoptosis, our results suggest that FA exerts its anti-apoptotic effects on neuronal cells, probably through its inhibitory effect on the outward K+ currents.zh_CN
dc.language.isoen_USzh_CN
dc.publisherCAN J PHYSIOL PHARMzh_CN
dc.source.urihttp://dx.doi.org/10.1139/Y11-083zh_CN
dc.subjectLYMPHOHEMATOPOIETIC MALIGNANCIESzh_CN
dc.subjectINHALATION EXPOSUREzh_CN
dc.subjectGAS-CHROMATOGRAPHYzh_CN
dc.subjectFISCHER-344 RATSzh_CN
dc.subjectACTIVATIONzh_CN
dc.subjectEXPRESSIONzh_CN
dc.subjectINDUSTRIESzh_CN
dc.subjectINCREASESzh_CN
dc.subjectMORTALITYzh_CN
dc.subjectWORKERSzh_CN
dc.titleFormaldehyde suppresses neuronal apoptosis via inhibition of outward K+ currents in rat hippocampuszh_CN
dc.typeArticlezh_CN


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