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dc.contributor.authorXie, Baiyizh_CN
dc.contributor.authorChen, Jibingzh_CN
dc.contributor.authorXia, Junjiezh_CN
dc.contributor.authorWang, Yongzhizh_CN
dc.contributor.authorLiang, Huazh_CN
dc.contributor.authorEkberg, Henrikzh_CN
dc.contributor.authorCorbascio, Matthiaszh_CN
dc.contributor.authorQi, Zhongquanzh_CN
dc.contributor.author陈继冰zh_CN
dc.contributor.author梁华zh_CN
dc.contributor.author齐忠权zh_CN
dc.date.accessioned2015-07-22T07:36:30Z
dc.date.available2015-07-22T07:36:30Z
dc.date.issued2009zh_CN
dc.identifier.citationIMMUNOLOGICAL INVESTIGATIONS, 2009,38(7):639-651zh_CN
dc.identifier.otherWOS:000271275000007zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93170
dc.description.abstractDonor-reactive memory T cells threaten the survival of transplanted organs via multiple pathways. This study was undertaken to induce tolerance of cardiac allografts in mice, in which alloreactive memory T cells were adoptively transferred, by combined costimulatory blockade of both effector and memory T cells. We found that the median survival time (MST) of the grafts was 5.17 days in the untreated group, 10.33 days in the CTLA4Ig- and antiCD40L- treated (2-combined) group, and more than 100 days in the CTLA4Ig-, anti-CD40L-, anti-LFA-1-, and anti-OX40L-treated (4-combined) group. Histological analysis revealed that the mean rejection level was Grade 4 in the untreated group, Grade 3 in the 2-combined treatment group, and Grade 0 in the 4-combined treatment group. CD44(high) T cells were detected only in the untreated group. The in vitro proliferation of lymphocytes of both untreated and 2-combined group was higher than that of the 4-combined treatment group (p < 0.01). Compared with the untreated group, the expression levels of IL-2, IFN-gamma, and Foxp3 were lower in the 2-combined treatment group; the expression levels of these genes were the lowest in the 4-combined treatment group. IL-10 expression was significantly higher in the 4-combined treatment group than in the other groups. These results demonstrate the inhibition efficacy of combined costimulation blockade in accelerated-rejection models and the possible mechanisms underlying the suppression of cellular immunity in mice receiving grafts as well as in inducing the activation of IL-10-producing Tr1 cells in grafts.zh_CN
dc.language.isoen_USzh_CN
dc.publisherIMMUNOL INVESTzh_CN
dc.source.urihttp://dx.doi.org/10.1080/08820130903062228zh_CN
dc.subjectALLOGRAFT-REJECTIONzh_CN
dc.subjectMONOCLONAL-ANTIBODYzh_CN
dc.subjectCARDIAC ALLOGRAFTzh_CN
dc.subjectOX40zh_CN
dc.subjectTOLERANCEzh_CN
dc.subjectEFFECTORzh_CN
dc.subjectSURVIVALzh_CN
dc.subjectTRANSPLANTATIONzh_CN
dc.subjectALLORESPONSEzh_CN
dc.subjectINDUCTIONzh_CN
dc.titleCombined Costimulation Blockade Inhibits Accelerated Rejection Mediated by Alloantigen-primed Memory T Cells in Micezh_CN
dc.typeArticlezh_CN


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