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dc.contributor.authorChen, Lukuizh_CN
dc.contributor.authorLiu, Yunshengzh_CN
dc.contributor.authorHou, Yonghongzh_CN
dc.contributor.authorKato, Yokozh_CN
dc.contributor.authorSano, Hirotoshizh_CN
dc.contributor.authorKanno, Tetsuozh_CN
dc.contributor.author陈陆馗zh_CN
dc.date.accessioned2015-07-22T07:36:26Z
dc.date.available2015-07-22T07:36:26Z
dc.date.issued2007-04-24zh_CN
dc.identifier.citationNEUROSCIENCE LETTERS, 2007,417(1):30-35zh_CN
dc.identifier.otherWOS:000246492000007zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93139
dc.description.abstractPituitary adenomas are frequently invasive of surrounding tissues, which adversely affects the surgical outcome and the disease-free survival of patients. In the present study, Interleukin 4 receptor (IL-4R) complex has been investigated to figure out whether the three subunits are overexpressed in human invasive pituitary adenomas. Reverse transcription-polymerise chain reaction (RT-PCR) analysis for interleukin 4 receptor a (IL-4R alpha), interleukin 13 receptor alpha 1 (IL-13R alpha 1), interleukin 2 receptor gamma c (IL-2R gamma c) were performed on total RNA extracted from 10 non-invasive pituitary adenomas, 30 invasive pituitary adenomas, one glioblastoma multiforme, one normal human pituitary tissue sample and one normal human brain tissue sample. Quantitative real-time PCR and in situ immunofluorescence assay were performed in five invasive functioning pituitary adenoma samples and five invasive nonfunctioning pituitary adenoma samples. RT-PCR analysis for IL-4Ra, IL-13R alpha 1 and IL-2R gamma c chains were overexpressed in invasive pituitary adenomas. The transcripts for three subunits were not/weakly expressed in normal pituitary tissue and normal brain tissue. The quantitative real-time PCR and in situ immunofluorescence assay confirmed the results of the RT-PCR analysis. Our results indicate that human invasive pituitary adenomas express type III IL-4R complex. These receptors may serve as a novel target for immunotoxin therapy in patients with invasive pituitary adenomas who are not amenable to total surgical resection or for recurrent cases. (c) 2007 Elsevier Ireland Ltd. All rights reserved.zh_CN
dc.language.isoen_USzh_CN
dc.publisherNEUROSCI LETTzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.neulet.2007.02.070zh_CN
dc.subjectRENAL-CELL CARCINOMAzh_CN
dc.subjectHUMAN BRAIN-TUMORSzh_CN
dc.subjectPSEUDOMONAS EXOTOXINzh_CN
dc.subjectCANCER-THERAPYzh_CN
dc.subjectFUSION PROTEINzh_CN
dc.subjectIN-VITROzh_CN
dc.subjectLYMPHOKINEzh_CN
dc.subjectCYTOTOXINzh_CN
dc.subjectCHAINzh_CN
dc.subjectGLIOBLASTOMAzh_CN
dc.titleExpression and structure of interleukin 4 receptor (IL-4R) complex in human invasive pituitary adenomaszh_CN
dc.typeArticlezh_CN


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