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dc.contributor.authorXiong, Yuzh_CN
dc.contributor.authorLu, Qing-Junzh_CN
dc.contributor.authorZhao, Jingzh_CN
dc.contributor.authorWu, Guo-Yangzh_CN
dc.contributor.author熊宇zh_CN
dc.contributor.author吴国洋zh_CN
dc.date.accessioned2015-07-22T07:36:23Z
dc.date.available2015-07-22T07:36:23Z
dc.date.issued2012zh_CN
dc.identifier.citationASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2012,13(7):3275-3279zh_CN
dc.identifier.otherWOS:000309476000045zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93123
dc.descriptionNational science and technology special foundation for major infectious diseases prevention and control [2008Ex 10002019]zh_CN
dc.description.abstractRecently, population-based studies of type 2 diabetes patients have provided evidence that metformin treatment is associated with a reduced cancer incidence and mortality, but its mode of action remains unclean Here we report effects of metformin on hepatocellular carcinoma (HCC) Hep-G2 cells and details of molecular mechanisms of metformin activity. Our research indicates that metformin displays anticancer activity against HCC through inhibition of the mTOR translational pathway in an AMPK-independent manner, leading to G1 arrest in the cell-cycle and subsequent cell apoptosis through the mitochondrion-dependent pathway. Furthermore, we showed that metformin strongly attenuated colony formation and dramatically inhibited Hep-G2 tumor growth in vivo. In conclusion, our studies suggested that metformin might have potential as a cytotoxic drug in the prevention and treatment of HCC.zh_CN
dc.language.isoen_USzh_CN
dc.publisherASIAN PAC J CANCER Pzh_CN
dc.source.urihttp://dx.doi.org/10.7314/APJCP.2012.13.7.3275zh_CN
dc.subjectBREAST-CANCER CELLSzh_CN
dc.subjectPANCREATIC-CANCERzh_CN
dc.subjectRISKzh_CN
dc.subjectTHERAPIESzh_CN
dc.subjectKINASEzh_CN
dc.subjectTRANSLATIONzh_CN
dc.subjectMETABOLISMzh_CN
dc.subjectTARGETzh_CN
dc.subjectCOHORTzh_CN
dc.titleMetformin Inhibits Growth of Hepatocellular Carcinoma Cells by Inducing Apoptosis Via Mitochondrion-mediated Pathwayzh_CN
dc.typeArticlezh_CN


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