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dc.contributor.authorMatheoud, Dianazh_CN
dc.contributor.authorMoradin, Nedazh_CN
dc.contributor.authorBellemare-Pelletier, Angeliquezh_CN
dc.contributor.authorShio, Marina Tiemizh_CN
dc.contributor.authorHong, Wan Jinzh_CN
dc.contributor.authorOlivier, Martinzh_CN
dc.contributor.authorGagnon, Etiennezh_CN
dc.contributor.authorDesjardins, Michelzh_CN
dc.contributor.authorDescoteaux, Albertzh_CN
dc.contributor.author洪万进zh_CN
dc.date.accessioned2015-07-22T07:35:04Z
dc.date.available2015-07-22T07:35:04Z
dc.date.issued2013-Jul 17zh_CN
dc.identifier.citationCELL HOST & MICROBE, 2013,14(1):15-25zh_CN
dc.identifier.otherWOS:000330851300006zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93070
dc.descriptionCanadian Institutes of Health Research [MOP-114869, MOP-125990]; Canada Research Chair in Infection and Immunity; Canadian Research Chair in Cellular Microbiology; Fondation Armand-Frappier; Fonds Quebecois de la Recherche sur la Nature et les Technologieszh_CN
dc.description.abstractDuring phagocytosis, microorganisms are taken up by immune cells into phagosomes. Through membrane-trafficking events mediated by SNARE proteins, phagosomes fuse with lysosomes, generating degradative phagolysosomes. Phagolysosomes contribute to host immunity by linking microbial killing within these organelles with antigen processing for presentation on MHC class I or II molecules to T cells. We show that the intracellular parasite Leishmania evades immune recognition by inhibiting phagolysosome biogenesis. The Leishmania cell surface metalloprotease GP63 cleaves a subset of SNAREs, including VAMP8. GP63-mediated VAMP8 inactivation or Vamp8 disruption prevents the NADPH oxidase complex from assembling on phagosomes, thus altering their pH and degradative properties. Consequently, the presentation of exogenous Leishmania antigens on MHC class I molecules, also known as cross-presentation, is inhibited, resulting in reduced T cell activation. These findings indicate that Leishmania subverts immune recognition by altering phagosome function and highlight the importance of VAMP8 in phagosome biogenesis and antigen cross-presentation.zh_CN
dc.language.isoen_USzh_CN
dc.publisherCELL PRESSzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.chom.2013.06.003zh_CN
dc.subjectCD8(+) T-CELLSzh_CN
dc.subjectDENDRITIC CELLSzh_CN
dc.subjectMOLECULAR CHARACTERIZATIONzh_CN
dc.subjectCYTOKINE SECRETIONzh_CN
dc.subjectADAPTIVE IMMUNITYzh_CN
dc.subjectFUSION PROPERTIESzh_CN
dc.subjectNADPH OXIDASEzh_CN
dc.subjectPHAGOSOMEzh_CN
dc.subjectPROTEINzh_CN
dc.subjectLIPOPHOSPHOGLYCANzh_CN
dc.titleLeishmania Evades Host Immunity by Inhibiting Antigen Cross-Presentation through Direct Cleavage of the SNARE VAMP8zh_CN
dc.typeArticlezh_CN


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