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dc.contributor.authorKolluri, Siva Kumarzh_CN
dc.contributor.authorZhu, Xiuwenzh_CN
dc.contributor.authorZhou, Xinzh_CN
dc.contributor.authorLin, Bingzhenzh_CN
dc.contributor.authorChen, Yazh_CN
dc.contributor.authorSun, Kaizh_CN
dc.contributor.authorTian, Xuefeizh_CN
dc.contributor.authorTown, Jameszh_CN
dc.contributor.authorCao, Xihuazh_CN
dc.contributor.authorLin, Fengzh_CN
dc.contributor.authorZhai, Dayongzh_CN
dc.contributor.authorKitada, Shinichizh_CN
dc.contributor.authorLuciano, Frederickzh_CN
dc.contributor.authorO'Donnell, Edmondzh_CN
dc.contributor.authorCao, Yuzh_CN
dc.contributor.authorHe, Fengzh_CN
dc.contributor.authorLin, Jialingzh_CN
dc.contributor.authorReed, John C.zh_CN
dc.contributor.authorSatterzh_CN
dc.contributor.author张晓坤zh_CN
dc.date.accessioned2015-07-22T07:35:03Z
dc.date.available2015-07-22T07:35:03Z
dc.date.issued2008-10-07zh_CN
dc.identifier.citationCANCER CELL, 2008,14(4):285-298zh_CN
dc.identifier.otherWOS:000259896500004zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/93065
dc.descriptionNational Institutes of Health [CA109345, CA119785, GM060554, GM062964]; US Army Medical Research and Material Command [W81XWH-08-1-0478, DAMD17-03-1-0427]; California Tobacco-Related Diseases Research Program (CTRDRP) [11RT-0081]; California Breast Cancerzh_CN
dc.description.abstractBcl-2 can be converted into a proapoptotic molecule by nuclear receptor Nur77. However, the development of Bcl-2 converters as anticancer therapeutics has not been explored. Here we report the identification of a Nur77-derived Bcl-2-converting peptide with 9 amino acids (NuBCP-9) and its enantiomer, which induce apoptosis of cancer cells in vitro and in animals. The apoptotic effect of NuBCPs and their activation of Bax are not inhibited but rather potentiated by Bcl-2. NuBCP-9 and its enantiomer bind to the Bcl-2 loop, Which shares the characteristics of structurally adaptable regions with many cancer-associated and signaling proteins. NuBCP-9s act as molecular switches to dislodge the Bcl-2 BH4 domain, exposing its BH3 domain, which in turn blocks the activity of antiapoptotic Bcl-X-L.zh_CN
dc.language.isoen_USzh_CN
dc.publisherCANCER CELLzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.ccr.2008.09.002zh_CN
dc.subjectCELL-DEATHzh_CN
dc.subjectBH3-ONLY PROTEINSzh_CN
dc.subjectFAMILY PROTEINSzh_CN
dc.subjectBH3 DOMAINzh_CN
dc.subjectMITOCHONDRIAL APOPTOSISzh_CN
dc.subjectINDUCE APOPTOSISzh_CN
dc.subjectFLEXIBLE LOOPzh_CN
dc.subjectSOLID TUMORSzh_CN
dc.subjectBAXzh_CN
dc.subjectACTIVATIONzh_CN
dc.titleA short Nur77-derived peptide converts Bcl-2 from a protector to a killerzh_CN
dc.typeArticlezh_CN


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