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dc.contributor.authorLiu, Jie
dc.contributor.authorWu, Jianlin
dc.contributor.authorWang, Xiaoru
dc.contributor.author王小如
dc.contributor.authorCai, Zongwei
dc.date.accessioned2011-05-30T15:45:42Z
dc.date.available2011-05-30T15:45:42Z
dc.date.issued2007-08
dc.identifier.citationRAPID COMMUNICATIONS IN MASS SPECTROMETRY,2007,21(18):2992-2998zh_CN
dc.identifier.issn0951-4198
dc.identifier.urihttp://dx.doi.org/doi:10.1002/rcm.3182
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/9294
dc.description.abstractMetabolism of a mixture containing four dominant components in lipid solubles of Danshen was studied both in vitro and in vivo. The parent compounds and their metabolites were simultaneously detected by using liquid chromatography coupled with ion trap mass spectrometry. The results indicated that oxidation was the major pathway in phase I metabolism. O-Glucuronidation of the hydroxylated tanshinones was identified in the rat urine samples collected after the oral administration of the tanshinone components. The metabolic rates obtained from the in vitro metabolism study of each individual component were significantly different from those obtained from the incubation study of the four components in a cassette. Metabolite identification showed that tanshinone ITA and tanshinone I were the major metabolites of cryptotanshinone and dihydrotanshinone 1, respectively. The obtained results demonstrated the metabolic change between the active components in Danshen and suggested the need to study the multiple components or even the extract from the herbal medicines. Copyright (c) 2007 John Wiley & Sons, Ltd.zh_CN
dc.language.isoenzh_CN
dc.publisherJOHN WILEY & SONS LTDzh_CN
dc.titleStudy of the phase I and phase II metabolism of a mixture containing multiple tanshinones using liquid chromatography/tandem mass spectrometryzh_CN
dc.typeArticlezh_CN


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