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dc.contributor.authorHan, DaXiong
dc.contributor.authorChen, Weizhu
dc.contributor.authorHan, Bo
dc.contributor.authorZhao, Yufen
dc.contributor.author赵玉芬
dc.date.accessioned2011-05-29T15:25:55Z
dc.date.available2011-05-29T15:25:55Z
dc.date.issued2007
dc.identifier.citationSCIENCE IN CHINA SERIES C-LIFE SCIENCES,2007,50(5):580-586zh_CN
dc.identifier.issn1006-9305
dc.identifier.urihttp://dx.doi.org/doi:CNKI:SUN:JCXG.0.2007-05-002
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/9257
dc.description.abstractAmino acid homochirality, as a unique behavior of life, could have originated synchronously with the genetic code. In this paper, phosphoryl amino-acid -5'-nucleosides with P-N bond are postulated to be a chiral origin model in prebiotic molecular evolution. The enthalpy change in the intramolecular interaction between the nucleotide base and the amino-acid side-chain determines the stability of the particular complex, resulting in a preferred conformation associated with the chirality of amino acids. Based on the theoretical model, our experiments and calculations show that the chiral selection of the earliest amino acids for L-enantiomers seems to be a strict stereochemical/physicochernical determinism. As other amino acids developed blosynthetically from the earliest amino acids, we infer that the chirality of the later amino acids was inherited from the precursor amino acids. This idea probably goes far back in history, but it is hoped that it will be a guide for further experiments in this area.zh_CN
dc.language.isoenzh_CN
dc.publisherSCIENCE CHINA PRESSzh_CN
dc.subjectgenetic codezh_CN
dc.subjectphosphatezh_CN
dc.subjectorigin of lifezh_CN
dc.subjectchiral selectionzh_CN
dc.subjecthomochiralityzh_CN
dc.titleA new theoretical model for the origin of amino acid homochiralityzh_CN
dc.typeArticlezh_CN


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