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A new theoretical model for the origin of amino acid homochirality

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A new theoretical model for the origin of amino acid homochirality.htm (110bytes)
发布日期
2007
作者
Han, DaXiong
Chen, Weizhu
Han, Bo
Zhao, Yufen
赵玉芬
所在专题
  • 化学化工-已发表论文 [14235]
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摘要
Amino acid homochirality, as a unique behavior of life, could have originated synchronously with the genetic code. In this paper, phosphoryl amino-acid -5'-nucleosides with P-N bond are postulated to be a chiral origin model in prebiotic molecular evolution. The enthalpy change in the intramolecular interaction between the nucleotide base and the amino-acid side-chain determines the stability of the particular complex, resulting in a preferred conformation associated with the chirality of amino acids. Based on the theoretical model, our experiments and calculations show that the chiral selection of the earliest amino acids for L-enantiomers seems to be a strict stereochemical/physicochernical determinism. As other amino acids developed blosynthetically from the earliest amino acids, we infer that the chirality of the later amino acids was inherited from the precursor amino acids. This idea probably goes far back in history, but it is hoped that it will be a guide for further experiments in this area.
出处
SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2007,50(5):580-586
本条目访问地址(URI)
http://dx.doi.org/doi:CNKI:SUN:JCXG.0.2007-05-002
https://dspace.xmu.edu.cn/handle/2288/9257

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