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dc.contributor.authorBao, Jianfengzh_CN
dc.contributor.authorCui, Xiaohongzh_CN
dc.contributor.authorCai, Shuhuizh_CN
dc.contributor.authorZhong, Jianhuizh_CN
dc.contributor.authorCai, Congbozh_CN
dc.contributor.authorChen, Zhongzh_CN
dc.contributor.author崔晓红zh_CN
dc.contributor.author蔡淑惠zh_CN
dc.contributor.author蔡聪波zh_CN
dc.contributor.author陈忠zh_CN
dc.date.accessioned2015-07-22T07:23:36Z
dc.date.available2015-07-22T07:23:36Z
dc.date.issued2013zh_CN
dc.identifier.citationNMR IN BIOMEDICINE, 2013,26(12):1663-1671zh_CN
dc.identifier.otherWOS:000327157400005zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/91784
dc.descriptionNational Natural Science Foundation (NNSF) of China [11174239, 11074209, 81171331]; Fundamental Research Fund for the Central Universities [2010121008, 2010121101]zh_CN
dc.description.abstractBrown adipose tissue (BAT) is a promising therapeutic target in obesity studies. Recently, MRI has been proposed for the mapping of BAT. However, because of the limitation of spatial resolution, similar to the existing positron emission tomography and computed tomography techniques for BAT detection, it fails to distinguish BAT cells when they are mixed with other cells. In this work, a new MRI method is proposed, combining intermolecular double-quantum coherence and the chemical shift-encoded Dixon method. Its contrast depends on the water to fat ratio at the cellular scale, which is smaller than the imaging voxel size. The feasibility of this MRI method was shown with computer simulations and phantoms, and preliminary imaging of BAT of rats at 7 T. Both computer simulations and experimental results are consistent with theoretical predictions. The method provides a novel contrast mechanism and can map BAT distribution exclusively. In particular, a mixture of BAT cells and white adipose tissue cells was detected in an older rat, which was undetectable by other noninvasive methods. This method may be applicable to a wide range of uses in BAT-related studies, including the formation and variation of BAT. Copyright (c) 2013 John Wiley & Sons, Ltd.zh_CN
dc.language.isoen_USzh_CN
dc.publisherWILEY-BLACKWELLzh_CN
dc.source.urihttp://dx.doi.org/10.1002/nbm.3000zh_CN
dc.subjectIN-VIVOzh_CN
dc.subjectIDENTIFICATIONzh_CN
dc.subjectMICEzh_CN
dc.subjectSPECTROSCOPYzh_CN
dc.subjectEFFICIENTzh_CN
dc.subjectHUMANSzh_CN
dc.subjectIDEALzh_CN
dc.subjectMAPzh_CN
dc.titleBrown adipose tissue mapping in rats with combined intermolecular double-quantum coherence and Dixon water-fat MRIzh_CN
dc.typeArticlezh_CN


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