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dc.contributor.authorWang, Zhan-xiang(Fujian Med Univ, Hosp Xiamen 1, Dept Neurosurg)
dc.contributor.authorChen, Yu-ying
dc.contributor.authorLi, Bo-an
dc.contributor.author李博安
dc.contributor.authorTan, Guo-wei
dc.contributor.authorLiu, Xi-yao
dc.contributor.authorShen, Shang-hang
dc.contributor.authorZhu, Hong-wei
dc.contributor.authorWang, Hai-dong
dc.date.accessioned2011-05-23T07:33:32Z
dc.date.available2011-05-23T07:33:32Z
dc.date.issued2010
dc.identifier.citationJournal of Neuro-Oncology,Volume 100, Number 1, 31-41zh_CN
dc.identifier.issn0167-594X
dc.identifier.urihttp://dx.doi.org/doi:10.1007/s11060-010-0144-6
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/9082
dc.description.abstractGliomas are common malignant tumors of the human neural system, and Wnt signaling activation is closely related to glioma malignancy. Human Pygopus 2 (Pygo2) was recently discovered to be a component of the Wnt signaling pathway, which is required for beta-catenin/Tcf-dependent transcription. However, the role of Pygo2 in glioblastoma cell growth and survival remains uncertain. In the present study, Pygo2 expression was evaluated in 80 glioma tissue samples. Results demonstrated that tumor grade exhibited a positive correlation with overexpression of Pygo2. In addition, small hairpin RNA (shRNA) was used to specifically knockdown Pygo2 expression in human glioblastoma U251 cell lines. Results showed that inhibition of Pygo2 expression resulted in inhibited cell proliferation and invasiveness, as well as increased cell cycle arrest at the G(1) stage and decreased expression of the Wnt target gene cyclin D1. These results demonstrated that Pygo2 was highly expressed in glioma tissue and required for growth of glioblastoma cells.zh_CN
dc.description.sponsorshipNational Personnel Ministry Foundation [2004003]; Science and Technology Bureau Foundation of Xiamen City [3502z20089001, 3502Z20077055]; Health Bureau Foundation of Xiamen City [WSK0519, 2004017]; China Postdoctoral Science Foundation [20080440728]; Natural Science Foundation of Fujian [2009D002]zh_CN
dc.language.isoenzh_CN
dc.publisherSPRINGERzh_CN
dc.subjectPygo2zh_CN
dc.subjectGliomazh_CN
dc.subjectWnt signalingzh_CN
dc.subjectshRNAzh_CN
dc.titleDecreased pygopus 2 expression suppresses glioblastoma U251 cell growthzh_CN
dc.typeArticlezh_CN


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