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dc.contributor.authorCheng, W.zh_CN
dc.contributor.authorSong, C.zh_CN
dc.contributor.authorAnjum, K. M.zh_CN
dc.contributor.authorChen, M.zh_CN
dc.contributor.authorLi, D.zh_CN
dc.contributor.authorZhou, H.zh_CN
dc.contributor.authorWang, W.zh_CN
dc.contributor.authorChen, J.zh_CN
dc.contributor.author陈美zh_CN
dc.contributor.author王伟zh_CN
dc.date.accessioned2015-07-22T07:13:45Z
dc.date.available2015-07-22T07:13:45Z
dc.date.issued2011-08zh_CN
dc.identifier.citationINTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2011,38(4):331-337zh_CN
dc.identifier.otherWOS:000292335800010zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/90518
dc.descriptionMinistry of Science and Technology of China [2009DFA32760]; State Oceanic Administration [201005022-1]zh_CN
dc.description.abstractCoenzyme Q (CoQ or ubiquinone) is a lipid-soluble component of virtually all types of cell membranes and has been shown to play multiple metabolic functions. Several clinical diseases including encephalomyopathy, cerebellar ataxia and isolated myopathy were shown to be associated with CoQ deficiency. However, the role of CoQ in immunity has not been defined. In the present study, we showed that flies defective in CoQ biosynthetic gene coq2 were more susceptible to bacterial and fungal infections, while were more resistant to viruses. We found that Drosophila contained both CoQ9 and CoQ10, and food supplement of CoQ10 could partially rescue the impaired immune functions of coq2 mutants. Surprisingly, wild-type flies fed CoQ10 became more susceptible to viral infection, which suggested that extra caution should be taken when using CoQ10 as a food supplement. We further showed that CoQ was essential for normal induction of anti-microbial peptides and amplification of viruses. Our work determined CoQ content in Drosophila and described its function in immunity for the first time.zh_CN
dc.language.isoen_USzh_CN
dc.publisherINT J IMMUNOGENETzh_CN
dc.source.urihttp://dx.doi.org/10.1111/j.1744-313X.2011.01012.xzh_CN
dc.subjectHOST-DEFENSEzh_CN
dc.subjectUBIQUINONE DEFICIENCYzh_CN
dc.subjectRESPIRATORY-CHAINzh_CN
dc.subjectGENEzh_CN
dc.subjectMELANOGASTERzh_CN
dc.subjectQ(10)zh_CN
dc.subjectMUTATIONSzh_CN
dc.subjectCOQ2zh_CN
dc.titleCoenzyme Q plays opposing roles on bacteria/fungi and viruses in Drosophila innate immunityzh_CN
dc.typeArticlezh_CN


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