Show simple item record

dc.contributor.authorLi, Jinquanzh_CN
dc.contributor.authorZhao, Zhenghuanzh_CN
dc.contributor.authorFeng, Jianghuazh_CN
dc.contributor.authorGao, Jinhaozh_CN
dc.contributor.authorChen, Zhongzh_CN
dc.contributor.author高锦豪zh_CN
dc.contributor.author陈忠zh_CN
dc.date.accessioned2015-07-22T03:20:23Z
dc.date.available2015-07-22T03:20:23Z
dc.date.issued2013-Nov 15zh_CN
dc.identifier.citationNANOTECHNOLOGY, 2013,24(45)zh_CN
dc.identifier.otherWOS:000326081400005zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/88788
dc.descriptionNational Natural Science Foundation of China [20605025, 81272581]; Fundamental Research Funds for the Central Universities [2011121046]zh_CN
dc.description.abstractRecently, some types of MnO nanoparticle (Mn-NP) with favorable imaging capacity have been developed to improve the biocompatible profile of the existing Mn-based MRI contrast agent Mn-DPDP; however, the overall bio-effects and potential toxicity remain largely unknown. In this study, H-1 NMR-based metabolic profiling, integrated with traditional biochemical analysis and histopathological examinations, was used to investigate the absorption, distribution, metabolism, excretion and toxicity of Mn-NPs as candidates for MRI contrast agent. The metabolic responses in biofluids (plasma and urine) and tissues (liver, spleen, kidney, lung and brain) from rats could be divided into four classes following Mn-NP administration: Mn biodistribution-dependent, time-dependent, dose-dependent and complicated metabolic variations. The variations of these metabolites involved in lipid, energy, amino acid and other nutrient metabolism, which disclosed the metabolic fate and biological effects of Mn-NPs in rats. The changes of metabolic profile implied that the disturbance and impairment of biological functions induced by Mn-NP exposure were correlated with the particle size and the surface chemistry of nanoparticles. Integration of metabonomic technology with traditional methods provides a promising tool to understand the toxicological behavior of biomedical nanomaterials and will result in informed decision-making during drug development.zh_CN
dc.language.isoen_USzh_CN
dc.publisherIOP PUBLISHING LTDzh_CN
dc.source.urihttp://dx.doi.org/10.1088/0957-4484/24/45/455102zh_CN
dc.subjectMANGANESEzh_CN
dc.subjectTOXICITYzh_CN
dc.subjectSTRESSzh_CN
dc.subjectTISSUEzh_CN
dc.subjectBRAINzh_CN
dc.subjectRATSzh_CN
dc.titleUnderstanding the metabolic fate and assessing the biosafety of MnO nanoparticles by metabonomic analysiszh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record