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dc.contributor.authorWeng, Wenzh_CN
dc.contributor.authorLe Zeng, Qingzh_CN
dc.contributor.authorYao, Bi Xiazh_CN
dc.contributor.authorLin, Wen Shizh_CN
dc.contributor.authorWang, Qing Huazh_CN
dc.contributor.authorYou, Xiu Lizh_CN
dc.contributor.author尤秀丽zh_CN
dc.date.accessioned2015-07-22T03:19:59Z
dc.date.available2015-07-22T03:19:59Z
dc.date.issued2006-10zh_CN
dc.identifier.citationCHROMATOGRAPHIA, 2006,64:463-467zh_CN
dc.identifier.otherWOS:000241507600015zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/88545
dc.description.abstractFive structurally related amino acid derivatives were enantioseparated by HPLC with a commercially available chiral stationary phase, Chiralcel OD-H. The chromatographic experiments were performed in the normal phase mode. n-Hexane/polar alcohol was used as mobile phase. Excellent baseline enantioseparations could be obtained for all these solutes. The effects of the concentration of polar alcohol and the column temperature on the retentions and enantioseparations were studied in detail. From the van't Hoff plots the corresponding apparent thermodynamic parameters were derived. Mechanism aspects of chiral recognition were discussed based on the relationship between the thermodynamic parameters and the structures of the solutes. It was found that the substituent of the phenyl group on the residual group of the amino acid derivatives was close relevant to thermodynamic origin of enantioseparation. Much better enthalpy-entropy compensation effect was obtained by plotting the differential, rather than the original, thermodynamic parameters.zh_CN
dc.language.isoen_USzh_CN
dc.publisherCHROMATOGRAPHIAzh_CN
dc.source.urihttp://dx.doi.org/10.1365/s10337-006-0040-6zh_CN
dc.subjectPERFORMANCE LIQUID-CHROMATOGRAPHYzh_CN
dc.subjectENTHALPY-ENTROPY COMPENSATIONzh_CN
dc.subjectPROPRANOLOL ENANTIOMERSzh_CN
dc.subjectDANSYL-AMINOzh_CN
dc.subjectSEPARATIONzh_CN
dc.subjectRECOGNITIONzh_CN
dc.subjectTEMPERATUREzh_CN
dc.subjectCYCLODEXTRINzh_CN
dc.subjectENANTIOSELECTIVITYzh_CN
dc.subjectTHERMODYNAMICSzh_CN
dc.titleEnantioseparation of amino acid derivatives with a cellulose-based chiral stationary phasezh_CN
dc.typeArticlezh_CN


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