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dc.contributor.authorNie, Limingzh_CN
dc.contributor.authorHuang, Pengzh_CN
dc.contributor.authorLi, Weitaozh_CN
dc.contributor.authorYan, Xuefengzh_CN
dc.contributor.authorJin, Albertzh_CN
dc.contributor.authorWang, Zhezh_CN
dc.contributor.authorTang, Yuxiazh_CN
dc.contributor.authorWang, Shoujuzh_CN
dc.contributor.authorZhang, Xiaofenzh_CN
dc.contributor.authorNiu, Gangzh_CN
dc.contributor.authorChen, Xiaoyuanzh_CN
dc.contributor.author陈小元zh_CN
dc.date.accessioned2015-07-22T03:06:51Z
dc.date.available2015-07-22T03:06:51Z
dc.date.issued2014 December 23zh_CN
dc.identifier.citationACS Nano, 2014,8(12):12141-12150zh_CN
dc.identifier.issn1936-0851zh_CN
dc.identifier.other20145200380284zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/87606
dc.description.abstractConventional evaluation methods of chemotherapeutic efficacy such as tissue biopsy and anatomical measurement are either invasive with potential complications or dilatory to capture the rapid pathological changes. Here, a sensitive and resolution-scalable photoacoustic microscopy (PAM) with theranostic nanoformulation was developed to noninvasively monitor the therapy response in a timely manner. Ultrasmall graphene oxide nanosheets were designed as both drug-loading vehicle and photoacoustic signal amplifier to the tumor. With the signal enhancement by the injected contrast agents, the subtle microvascular changes of the chemotherapy response in tumor were advantagely revealed by our PAM system, which was much earlier than the morphological measurement by standard imaging techniques. High tumor uptake of the enhanced nanodrug with Cy5.5 labeling was validated by fluorescence imaging. At different observation scales, PAM offered unprecedented sensitivity of optical absorption and high spatial resolution over optical imaging. Our studies demonstrate the PAM system with synergistic theranostic strategy to be a multiplexing platform for tumor diagnosis, drug delivery, and chemotherapy response monitoring at a very early stage and in an effective way.zh_CN
dc.language.isoen_USzh_CN
dc.publisherAmerican Chemical Societyzh_CN
dc.source.urihttp://dx.doi.org/10.1021/nn505989ezh_CN
dc.subjectAmplifiers (electronic)zh_CN
dc.subjectChemotherapyzh_CN
dc.subjectDiagnosiszh_CN
dc.subjectDrug deliveryzh_CN
dc.subjectEnzyme inhibitionzh_CN
dc.subjectGraphenezh_CN
dc.subjectImaging techniqueszh_CN
dc.subjectLight absorptionzh_CN
dc.subjectLoadingzh_CN
dc.subjectTumorszh_CN
dc.titleEarly-stage imaging of nanocarrier-enhanced chemotherapy response in living subjects by scalable photoacoustic microscopyzh_CN
dc.typeArticlezh_CN


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