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dc.contributor.authorZhang, Fanzh_CN
dc.contributor.authorHuang, Xingluzh_CN
dc.contributor.authorZhu, Leizh_CN
dc.contributor.authorGuo, Ningzh_CN
dc.contributor.authorNiu, Gangzh_CN
dc.contributor.authorSwierczewska, Magdalenazh_CN
dc.contributor.authorLee, Seulkizh_CN
dc.contributor.authorXu, Hongzh_CN
dc.contributor.authorWang, Andrew Y.zh_CN
dc.contributor.authorMohamedali, Khalid A.zh_CN
dc.contributor.authorRosenblum, Michael G.zh_CN
dc.contributor.authorLu, Guangmingzh_CN
dc.contributor.authorChen, Xiaoyuazh_CN
dc.contributor.author陈小元zh_CN
dc.date.accessioned2015-07-22T03:06:50Z
dc.date.available2015-07-22T03:06:50Z
dc.date.issued2012 Julyzh_CN
dc.identifier.citationBiomaterials, 2012,33(21):5414-5422zh_CN
dc.identifier.other20122015031700zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/87599
dc.description.abstractNoninvasive imaging techniques have been considered important strategies in the clinic to monitor tumor early response to therapy. In the present study, we applied RGD peptides conjugated to iron oxide nanoparticles (IONP-RGD) as contrast agents in magnetic resonance imaging (MRI) to noninvasively monitor the response of a vascular disrupting agent VEGF121/rGel in an orthotopic glioblastoma model. RGD peptides were firstly coupled to IONPs coated with a crosslinked PEGylated amphiphilic triblock copolymer. In vitro binding assays confirmed that cellular uptake of particles was mainly dependent on the interaction between RGD and integrin 伪v尾3 of human umbilical vein endothelial cells (HUVEC). The tumor targeting of IONP-RGD was observed in an orthotopic U87 glioblastoma model. Finally, noninvasive monitoring of the tumor response to VEGF121/rGel therapy at early stages of treatment was successfully accomplished using IONP-RGD as a contrast agent for MRI, a superior method over common anatomical approaches which are based on tumor size measurements. This preclinical study can accelerate anticancer drug development and promote clinical translation of nanoprobes. 漏 2012.zh_CN
dc.language.isoen_USzh_CN
dc.publisherElsevier Ltdzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.biomaterials.2012.04.032zh_CN
dc.subjectBlock copolymerszh_CN
dc.subjectEndothelial cellszh_CN
dc.subjectMagnetic resonance imagingzh_CN
dc.subjectMetal nanoparticleszh_CN
dc.subjectPeptideszh_CN
dc.titleNoninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticleszh_CN
dc.typeArticlezh_CN


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