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dc.contributor.authorSong, Xuejiaozh_CN
dc.contributor.authorGong, Huazh_CN
dc.contributor.authorYin, Shengnanzh_CN
dc.contributor.authorCheng, Liangzh_CN
dc.contributor.authorWang, Chaozh_CN
dc.contributor.authorLi, Zhiweizh_CN
dc.contributor.authorLi, Yonggangzh_CN
dc.contributor.authorWang, Xiaoyongzh_CN
dc.contributor.authorLiu, Gangzh_CN
dc.contributor.authorLiu, Zhuangzh_CN
dc.contributor.author刘刚zh_CN
dc.date.accessioned2015-07-22T03:06:49Z
dc.date.available2015-07-22T03:06:49Z
dc.date.issued2014 MARzh_CN
dc.identifier.citationADVANCED FUNCTIONAL MATERIALS, 2014,24(9):1194-1201zh_CN
dc.identifier.otherWOS:000332337000001zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/87591
dc.descriptionNational Natural Science Foundation of China [51222203, 51002100, 51132006]; National "973" Program of China [2012CB932601, 2013CB932702, 2011CB911002]; Priority Academic Program Development of Jiangsu Higher Education Institutions; Post-doctoral research program of Jiangsu Province [1202044C]zh_CN
dc.description.abstractRecently, near-infrared (NIR) absorbing conjugated polymeric nanoparticles have received significant attention in photothermal therapy of cancer. Herein, polypyrrole (PPy), a NIR-absorbing conjugate polymer, is used to coat ultra-small iron oxide nanoparticles (IONPs), obtaining multifunctional IONP@PPy nanocomposite which is further modified by the biocompatible polyethylene glycol (PEG) through a layer-by-layer method to acquire high stability in physiological solutions. Utilizing the optical and magnetic properties of the yielded IONP@PPy-PEG nanoparticles, in vivo magnetic resonance (MR) and photoacoustic imaging of tumor-bearing mice are conducted, revealing strong tumor uptake of those nanoparticles after intravenous injection. In vivo photothermal therapy is then designed and carried out, achieving excellent tumor ablation therapeutic effect in mice experiments. These results promise the use of multifunctional NIR-absorbing organic-inorganic hybrid nanomaterials, such as IONP@PPy-PEG presented here, for potential applications in cancer theranostics.zh_CN
dc.language.isoen_USzh_CN
dc.publisherWILEY-V C H VERLAG GMBHzh_CN
dc.source.urihttp://dx.doi.org/10.1002/adfm.201302463zh_CN
dc.subjectNEAR-INFRARED ABSORBENCYzh_CN
dc.subjectMAGNETIC NANOPARTICLESzh_CN
dc.subjectGOLD NANOCAGESzh_CN
dc.subjectCANCER-THERAPYzh_CN
dc.subjectBIOMEDICAL APPLICATIONSzh_CN
dc.subjectPOLYMER NANOPARTICLESzh_CN
dc.subjectCONDUCTING POLYMERzh_CN
dc.subjectCONTRAST AGENTSzh_CN
dc.subjectGRAPHENE OXIDEzh_CN
dc.subjectTISSUEzh_CN
dc.titleUltra- Small Iron Oxide Doped Polypyrrole Nanoparticles for In Vivo Multimodal Imaging Guided Photothermal Therapyzh_CN
dc.typeArticlezh_CN


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