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dc.contributor.authorMcLellan, Jason S.zh_CN
dc.contributor.authorChen, Manzh_CN
dc.contributor.authorLeung, Shermanzh_CN
dc.contributor.authorGraepel, Kevin W.zh_CN
dc.contributor.authorDu, Xiulianzh_CN
dc.contributor.authorYang, Yongpingzh_CN
dc.contributor.authorZhou, Tongqingzh_CN
dc.contributor.authorBaxa, Ulrichzh_CN
dc.contributor.authorYasuda, Etsukozh_CN
dc.contributor.authorBeaumont, Timzh_CN
dc.contributor.authorKumar, Azadzh_CN
dc.contributor.authorModjarrad, Kayvonzh_CN
dc.contributor.authorZheng, Zizhengzh_CN
dc.contributor.authorZhao, Minzh_CN
dc.contributor.authorXia, Ningshaozh_CN
dc.contributor.authorKwong, Peter D.zh_CN
dc.contributor.authorGrzh_CN
dc.contributor.author郑子峥zh_CN
dc.contributor.author夏宁邵zh_CN
dc.date.accessioned2015-07-22T03:06:45Z
dc.date.available2015-07-22T03:06:45Z
dc.date.issued2013-May 31zh_CN
dc.identifier.citationSCIENCE, 2013,340(6136):1113-1117zh_CN
dc.identifier.otherWOS:000319664500049zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/87567
dc.descriptionIntramural Research Program (National Institute of Allergy and Infectious Diseases); National Natural Science Foundation of China [81161120419]; U.S. Department of Energy, Basic Energy Sciences, Office of Science [W-31-109-Eng-38]zh_CN
dc.description.abstractThe prefusion state of respiratory syncytiat virus (RSV) fusion (F) glycoprotein is the target of most RSV-neutralizing activity in human sera, but its metastability has hindered characterization. To overcome this obstacle, we identified prefusion-specific antibodies that were substantially more potent than the prophylactic antibody palivizumab. The cocrystal structure for one of these antibodies, D25, in complex with the F glycoprotein revealed D25 to lock F in its prefusion state by binding to a quaternary epitope at the trimer apex. Electron microscopy showed that two other antibodies, AM22 and 5C4, also bound to the newly identified site of vulnerability, which we named antigenic site empty set. These studies should enable design of improved vaccine antigens and define new targets for passive prevention of RSV-induced disease,zh_CN
dc.language.isoen_USzh_CN
dc.publisherAMER ASSOC ADVANCEMENT SCIENCEzh_CN
dc.source.urihttp://dx.doi.org/10.1126/science.1234914zh_CN
dc.subjectRESPIRATORY SYNCYTIAL VIRUSzh_CN
dc.subjectMONOCLONAL-ANTIBODYzh_CN
dc.subjectF-GLYCOPROTEINzh_CN
dc.subjectPROTEINzh_CN
dc.subjectINFECTIONzh_CN
dc.subjectEPITOPESzh_CN
dc.subjectCONFORMATIONzh_CN
dc.subjectMOTAVIZUMABzh_CN
dc.subjectCHILDRENzh_CN
dc.subjectSEQUENCEzh_CN
dc.titleStructure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibodyzh_CN
dc.typeArticlezh_CN


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