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dc.contributor.authorXing, Ruijunzh_CN
dc.contributor.authorBhirde, Ashwinkumar A.zh_CN
dc.contributor.authorWang, Shoujuzh_CN
dc.contributor.authorSun, Xiaolianzh_CN
dc.contributor.authorLiu, Gangzh_CN
dc.contributor.authorHou, Yanglongzh_CN
dc.contributor.authorChen, Xiaoyuanzh_CN
dc.contributor.author刘刚zh_CN
dc.contributor.author陈小元zh_CN
dc.date.accessioned2015-07-22T03:06:43Z
dc.date.available2015-07-22T03:06:43Z
dc.date.issued2013zh_CN
dc.identifier.citationNANO RESEARCH, 2013,6(1):1-9zh_CN
dc.identifier.otherWOS:000313658800001zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/87552
dc.descriptionNational Basic Research Program of China (973 Program) [2013CB733802, 2010CB934602]; National Science Foundation of China (NSFC) [81101101, 81201086, 81201129, 81201190, 51273165, 51172005, 81028009]; Chinese Academy of Sciences Professorship for Senior International Scientists [2011T2J06]; Intramural Research Program (IRP) of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH); China Scholarship Councilzh_CN
dc.description.abstractMagnetic nanoparticles have been used as drug delivery vehicles against a number of cancer cells. Most of these theranostic formulations have used solid iron oxide nanoparticles (SIONPs) loaded with chemotherapeutics as nano-carrier formulation for both magnetic resonance imaging (MRI) and cancer therapy. In this study, we applied the dopamine-plus-human serum albumin (HSA) method to modify hollow iron oxide nanoparticles (HIONPs) and encapsuated doxorubicin (DOX) within the hollow porous structure of the nano-carrier. The new delivery system can load more drug than solid iron oxide nanoparticles of the same core size using the same coating strategy. The HIONPs-DOX formulation also has a pH-dependent drug release behaviour. Compared with free DOX, the HIONPs-DOX were more effectively uptaken by the multidrug resistant OVCAR8-ADR cells and consequently more potent in killing drug resistant cancer cells. MRI phantom and cell studies also showed that the HIONPs-DOX can decrease the T (2) MRI signal intensity and can be used as a MRI contrast agent while acting as a drug delivery vehicle. For the first time, the dual application of chemo drug transport and MR imaging using the HIONPs-DOX formulation was achieved against both DOX-sensitive and DOX-resistant cancer cells.zh_CN
dc.language.isoen_USzh_CN
dc.publisherTSINGHUA UNIV PRESSzh_CN
dc.source.urihttp://dx.doi.org/10.1007/s12274-012-0275-5zh_CN
dc.subjectMAGNETIC NANOPARTICLESzh_CN
dc.subjectFE3O4 NANOPARTICLESzh_CN
dc.subjectSOLID TUMORSzh_CN
dc.subjectCANCERzh_CN
dc.subjectDOXORUBICINzh_CN
dc.subjectRELEASEzh_CN
dc.subjectTUMORIGENESISzh_CN
dc.subjectMECHANISMSzh_CN
dc.subjectCONTRASTzh_CN
dc.subjectREVERSALzh_CN
dc.titleHollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicleszh_CN
dc.typeArticlezh_CN


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