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dc.contributor.authorZhang, Fanzh_CN
dc.contributor.authorHuang, Xingluzh_CN
dc.contributor.authorQian, Chunqizh_CN
dc.contributor.authorZhu, Leizh_CN
dc.contributor.authorHida, Naokizh_CN
dc.contributor.authorNiu, Gangzh_CN
dc.contributor.authorChen, Xiaoyuanzh_CN
dc.contributor.author朱雷zh_CN
dc.date.accessioned2015-07-22T03:06:41Z
dc.date.available2015-07-22T03:06:41Z
dc.date.issued2012-09-07zh_CN
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012,425(4):886-891zh_CN
dc.identifier.otherWOS:000309017700032zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/87544
dc.descriptionNational Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH); National Science Foundation of China (NSFC) [81201086]zh_CN
dc.description.abstractPurpose: The use of MR contrast agents allows accurate diagnosis by exerting an influence on the longitudinal (T-1) or transverse (T-2) relaxation time of the surrounding tissue. In this study, we combined the use of iron oxide (IO) particles and nonspecific extracellular gadolinium chelate (Gd) in order to further improve the sensitivity and specificity of lesion detection. Procedures: With a 7-Tesla scanner, pre-contrasted, IO-enhanced and dual contrast agent enhanced MRIs were performed in phantom, normal animals, and animal models of lymph node tumor metastases and orthotopic brain tumor. For the dual-contrast (DC) MRI, we focused on the evaluation of T-2 weighted DC MRI with IO administered first, then followed by the injection of a bolus of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA). Results: Based on the C/N ratios and MRI relaxometry, the synergistic effect of coordinated administration of Gd-DTPA and IO was observed and confirmed in phantom, normal liver and tumor models. At 30 min after administration of Feridex, Gd-DTPA further decreased T-2 relaxation in liver immediately after the injection. Additional administration of Gd-DTPA also immediately increased the signal contrast between tumor and brain parenchyma and maximized the C/N ratio to -4.12 +/- 0.71. Dual contrast MRI also enhanced the delineation of tumor borders and small lesions. Conclusions: DC-MRI will be helpful to improve diagnostic accuracy and decrease the threshold size for lesion detection. (C) 2012 Elsevier Inc. All rights reserved.zh_CN
dc.language.isoen_USzh_CN
dc.publisherBIOCHEM BIOPH RES COzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.bbrc.2012.07.168zh_CN
dc.subjectHEPATOCELLULAR-CARCINOMAzh_CN
dc.subjectHEPATIC METASTASESzh_CN
dc.subjectCIRRHOTIC LIVERzh_CN
dc.subjectDRUG DISCOVERYzh_CN
dc.subjectLYMPH-NODESzh_CN
dc.subjectGD-DTPAzh_CN
dc.subjectAGENTSzh_CN
dc.subjectLYMPHOGRAPHYzh_CN
dc.subjectCANCERzh_CN
dc.subjectINTEGRINzh_CN
dc.titleSynergistic enhancement of iron oxide nanoparticle and gadolinium for dual-contrast MRIzh_CN
dc.typeArticlezh_CN


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