High-Yield Fabrication of PLGA Non-Spherical Microarchitectures by Emulsion-Solvent Evaporation Method

Abstract

Recently, it has been recognized the shape of particles plays an essential role in the design of materials with unique properties. In this study, PLGA non-spherical microarchitectures, rods and fibers, were fabricated successfully in high yield by single emulsion-solvent evaporation method in the presence of sodium tripolyphosphate. The assay of PVA residue was carried out and the hydrogen bonds formation was verified as well. The presented data show that viscosity and coagulation agent have a synergistic effect on forming the rod- and fiber-like microarchitectures in the shear response and the formation mechanisms were proposed accordingly.