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Preparation and characterization of hydroxycamptothecin-loaded Poly(D,L-lactic acid) nanoparticles with high drug loading capacity

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Date
2012
Author
Hou, ZhenQing
Zhou, ShuiFan
Cui, Fei
Hang, YiXiao
Yi, YunFeng
侯振清
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  • 材料学院-会议论文 [72]
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Abstract
Hydroxycamptothecin (HCPT) loaded PLA nanoparticles were prepared by a facile dialysis method. Three main influential factors, PLA concentration, ratio of HCPT to PLA (wt/wt), dialysis bags with different molecule weight cutoff, were evaluated using an orthogonal design, gave the nanoparticles with an average diameter of approximately 226.8 nm and fine drug loading content (5.16%, w/w). The in vitro drug release studies exhibited a slow and prolonged release profile over 30 days. It is concluded that the new method to prepare HCPT-PLA nanoparticles resulted in improved formulation characteristics including small size, high drug loading capacity, and long sustained drug release.
Description
Conference Name:2nd International Conference on Material Engineering, Chemistry, Bioinformatics (MECB 2012). Conference Address: Xian, PEOPLES R CHINA. Time:JUL 14-15, 2012.
Citation
ADVANCED RESEARCH ON MATERIAL ENGINEERING, CHEMISTRY, BIOINFORMATICS II, 2012,531:503-506
URI
https://dspace.xmu.edu.cn/handle/2288/85103

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