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dc.contributor.authorChang, Dizh_CN
dc.contributor.authorHou, Zhenqingzh_CN
dc.contributor.authorYang, Xiangruizh_CN
dc.contributor.author侯振清zh_CN
dc.date.accessioned2015-07-22T01:36:54Z
dc.date.available2015-07-22T01:36:54Z
dc.date.issued2012zh_CN
dc.identifier.citationADVANCED RESEARCH ON MATERIAL ENGINEERING, CHEMISTRY, BIOINFORMATICS II, 2012,531:240-243zh_CN
dc.identifier.otherWOS:000312276800057zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/85102
dc.descriptionConference Name:2nd International Conference on Material Engineering, Chemistry, Bioinformatics (MECB 2012). Conference Address: Xian, PEOPLES R CHINA. Time:JUL 14-15, 2012.zh_CN
dc.description.abstractWe prepared FA-targeted and 10-hydroxycamptothecin loaded chitosan nanoparticles (FA-HCPT-NPs) with a combination of emulsion-solvent evaporation and chemical crosslinking method. In vitro cytotoxicity test to the Human Cervix Carcinoma cells (He La) was evaluated by cell morphology and internalization observation. The specicity of the FA-HCPT-NPs targeting cancerous cells was demonstrated by comparative intracellular uptake of HCPT-NPs and commercial availible HCPT injection. Laser confocal scanning imaging proved that FA-HCPT-NPs could greatly enhance up-take by He La cells. The morphological changes of He La cells showed the FA-HCPT-NPs could inhibit He La cells more effectively than HCPT-NPs and HCPT. The results indicated that the novel FA-HCPT-NPs could be a potential drug delivery system for tumor cell-selective targeting therapy.zh_CN
dc.language.isoen_USzh_CN
dc.publisherADV MATER RES-SWITZzh_CN
dc.source.urihttp://dx.doi.org/10.4028/www.scientific.net/AMR.531.240zh_CN
dc.subjectCELLULAR UPTAKEzh_CN
dc.subjectCAMPTOTHECINzh_CN
dc.subjectDERIVATIVESzh_CN
dc.subjectHYDROGELzh_CN
dc.subjectDELIVERYzh_CN
dc.subjectRECEPTORzh_CN
dc.titleIn Vitro Evaluation of Folate-targeted Chitosan Nanoparticles loaded With Hydroxycamptothecinzh_CN
dc.typeConferencezh_CN


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