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dc.contributor.author莫丽都尔zh_CN
dc.contributor.author陈汉zh_CN
dc.contributor.author李学敏zh_CN
dc.contributor.author陈红丽zh_CN
dc.contributor.author史艳萍zh_CN
dc.contributor.author张其清zh_CN
dc.date.accessioned2011-04-26T08:24:08Z
dc.date.available2011-04-26T08:24:08Z
dc.date.issued2007zh_CN
dc.identifier.citation中国新药杂志 Chinese Journal of New Drugs,2007,16(15):1187-1191zh_CN
dc.identifier.issn1003-3734zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/8504
dc.description.abstract目的:制备一种可用于关节腔注射的甲氨蝶呤(methotrexate,MTX)聚乳酸-聚羟基乙酸共聚物(PL-GA)缓释微球,并研究其体内外释药规律。方法:应用O/W溶剂挥发法制备MTX-PLGA微球,对其表面形态、粒径分布进行表征并测定其包封率、载药量和体内外释药谱;采用HPLC法分析药物含量;体内释放采用大鼠皮下气囊模型。结果:微球表面光滑圆整,平均粒径为(38.47±1.32)μm,包封率和载药量分别为(62.71±0.84)%和(3.23±0.13)%。体外释放t50为20 d,体外释放速率常数Kr=0.038μg.mL-1.d-1。体内试验显示,在气囊中的释放速率常数KR=0.12μg.mL-1.d-1。结论:采用本法制备的MTX-PLGA微球具有明显的缓释作用,有望成为一种有效的治疗类风湿关节炎的制剂。 【英文摘要】 Objective:To prepare methotrexate(MTX) loaded poly(DL-lactide-co-glycolide)(PLGA) microspheres for intra-articular administration and investigate their release profiles.Methods:Microspheres were prepared by oil-in-water emulsion solvent evaporation method.The surface morphology,size distribution,drug loading content and the encapsulation efficiency of microspheres were examined.The in vitro drug release profiles of the microspheres were measured in phosphate buffer saline(PBS,pH 7.40),and a rat air-pouch mo...zh_CN
dc.description.sponsorship国家重点科学研究计划项目(2006CB933300);; 博士点基金(96002323);; 厦门市科技计划项目(3502Z20055007)zh_CN
dc.language.isozhzh_CN
dc.publisher中国医药科技出版社;中国医药集团总公司;中国药学会zh_CN
dc.subject关节腔注射zh_CN
dc.subject甲氨蝶呤zh_CN
dc.subject聚乳酸-聚羟基乙酸共聚物zh_CN
dc.subject微球zh_CN
dc.subject体内外释放zh_CN
dc.subjectintra-articular injectionzh_CN
dc.subjectmethotrexatezh_CN
dc.subjectPLGAzh_CN
dc.subjectmicrosphereszh_CN
dc.subjectin vitro & in vivo releasezh_CN
dc.title关节腔注射用甲氨蝶呤缓释微球的制备及体内外释药研究zh_CN
dc.title.alternativePreparation and the in vitro and in vivo release of PLGA microspheres containing methotrexate for intra-articular injectionzh_CN
dc.typeArticlezh_CN


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