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dc.contributor.author宋闽宁zh_CN
dc.contributor.author陈福zh_CN
dc.contributor.author宋屿娜zh_CN
dc.contributor.author谢泽金zh_CN
dc.date.accessioned2011-04-26T08:24:08Z
dc.date.available2011-04-26T08:24:08Z
dc.date.issued2008zh_CN
dc.identifier.citation临床肝胆病杂志,Chinese Journal of Clinical Hepatology,2008,24(2):88-91zh_CN
dc.identifier.issn1001-5256zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/8498
dc.description.abstract的探讨五羟色胺(5-HT)在大鼠急性肝衰竭(ALF)肝性脑病(HE)发病中的影响。方法应用SD大鼠,随机分为正常对照A,观察组B、C、D,每组20只。B、C、D组分别应用5%硫代乙酰胺(TAA)500mg/kg灌胃,制作ALF HE动物模型。B组和C组分别加用塞庚啶10mg/kg、20mg/kg。各组分阶段观察5-HT,肝生化指标、血氨、内毒素检测值、脑核磁共振及脑组织病理学电镜检查。结果B、C、D组5-HT测定值明显高于正常对照组(t≥3.9,P<0.01)。B、C组死亡率低于D组(x2≥0.63,P<0.05)。D组72小时5-HT值明显高于D组48小时组(t=6.1,P<0.01)。B、C组脑组织电镜检查示神经元细胞肿胀,有髓样小体形成,D组脑组织神经元细胞固缩,染色质增生,髓鞘水肿变性明显,部分有分层断裂。结论肝衰竭肝性脑病时5-HT有异常升高。应用5-HT受体拮抗剂可见脑组织病理损伤较轻,死亡率降低。 【英文摘要】 Objective To explore the influence of 5-hydroxytryptamine on rat with hepatic encephalopathy(HE) in stage of acute liver failures(ALF).Methods Eighty Sprague-Dawley rats were divided into four groups randomly: Group A acted as control.Model of rat with HE were induced by 5% thioacetamide(TAA) intragastric administration in group B,C and D.Group B and C were given by 5-HT receptor blocking agent(Cyproheptadine) with 10 mg/kg and 20mg/kg respectively.Each group was detected by liver function tests,5-HT,blood ...zh_CN
dc.description.sponsorship厦门市科技局资助项目(3502z20034007)zh_CN
dc.language.isozhzh_CN
dc.publisher吉林大学白求恩医学部zh_CN
dc.subject大鼠zh_CN
dc.subject肝性脑病zh_CN
dc.subject5-羟色胺zh_CN
dc.subject5-羟色胺受体拮抗剂zh_CN
dc.subject脑组织病理zh_CN
dc.subjecthepatic encephalopathyzh_CN
dc.subjectratzh_CN
dc.subject5-hydroxytryptaminezh_CN
dc.subjectserotonin receptorzh_CN
dc.subjecthistopathologyzh_CN
dc.title五羟色胺对大鼠肝性脑病影响的研究zh_CN
dc.title.alternativeThe influence of 5-hydroxytryptamine on rat with hepatic encephalopathy.zh_CN
dc.typeArticlezh_CN


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