P38 MAPK信号传导通路与胃癌关系的研究现状

Abstract

丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)级联反应是细胞内重要的信号传导系统之一,参与细胞生长、发育、分化和凋亡等一系列生理、病理过程.P38MAPK信号传导通路是MAPK通路的分支之一,介导了应激、炎性细胞因子、细菌产物等多种刺激引起的细胞反应,对细胞周期调控具有重要作用.但对不同的胃癌细胞系,或者不同的刺激,P38通路的作用不完全相同,甚至可能相反.提示对P38通路的功能仍需进一步的研究,他可能是肿瘤治疗的新靶点. 【英文摘要】 The cascade reaction of mitogen-activated protein kinases(MAPKs) is one of the vital intracellular signal transduction systems,participating in many physiological progressions,such as cell growth,proliferation,differentiation and apoptosis.P38 is a member of MAPKs,mediating many cell reactions induced by stress,inflammatory cytokines or bacterial products and playing a key role in the regulation of cell cycle.For different cell lines of gastric carcinoma,P38 has different functions.The same phenomenon can b...