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dc.contributor.author朱梅湘zh_CN
dc.contributor.author吴振zh_CN
dc.contributor.author赵玉芬zh_CN
dc.date.accessioned2011-04-26T08:24:06Z
dc.date.available2011-04-26T08:24:06Z
dc.date.issued2009-03zh_CN
dc.identifier.citation厦门大学学报(自然科学版) Journal of Xiamen University(Natural Science),2009,48(2):228-231zh_CN
dc.identifier.issn0438-0479zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/8486
dc.description.abstractAZT的5′-二苯基系列磷酸酯衍生物在体外抗病毒实验中显示了良好的抗HIV病毒活性,具有开发为新型核苷类抗病毒药物的潜力.本文采用PCl3一锅法合成了系列核苷二苯基磷酸酯,并对其纯化后的化合物进行大鼠体内药物动力学规律评价.结果显示该系列衍生物的动力学表现和苯基上取代基的性质有直接联系,且均能改善对AZT的释放,有作为临床抗艾滋病治疗剂的可能. 【英文摘要】 Diaryl phosphates triester derivatives of AZT were demonstrated great in vitro anti-HIV activity.Five pro-drugs were synthesized through tricoordinated phosphate chemistry.The overall pharmacokinetics in rat plasma was associated with the structure of the diaryl phosphate triester compounds,the magnitude of which varied considerably with the nature of the aryl substituent.The diaryl phosphate triester pro-drugs of AZT proved the tendency of sustained release of AZT,longer residence time in vivo and increase...zh_CN
dc.description.sponsorship国家自然科学基金(20732004);; 中国科技部国际合作项目(2006DFA43030)资助zh_CN
dc.language.isozhzh_CN
dc.publisher厦门大学zh_CN
dc.subjectAZTzh_CN
dc.subject二苯基磷酸酯衍生物zh_CN
dc.subject抗HIVzh_CN
dc.subject合成zh_CN
dc.subject药物动力学zh_CN
dc.subjectdiaryl phosphate triester derivativeszh_CN
dc.subjectanti-HIV activityzh_CN
dc.subjectsynthesiszh_CN
dc.subjectpharmacokineticszh_CN
dc.title核苷二苯基磷酸酯的合成及大鼠体内药物动力学zh_CN
dc.title.alternativeSynthesis and Pharmacokinetics of Five Diaryl Phosphate Triester Derivatives of Zidovudinezh_CN
dc.typeArticlezh_CN


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