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dc.contributor.author杨文智zh_CN
dc.contributor.author李学敏zh_CN
dc.contributor.author陈红丽zh_CN
dc.contributor.author陈名懋zh_CN
dc.contributor.author刘玲蓉zh_CN
dc.contributor.author张其清zh_CN
dc.date.accessioned2011-04-26T08:24:06Z
dc.date.available2011-04-26T08:24:06Z
dc.date.issued2009zh_CN
dc.identifier.citation中国新药杂志 Chinese Journal of New Drugs,2009,18(1):73-78zh_CN
dc.identifier.issn1003-3734zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/8485
dc.description.abstract的:经琥珀酸间隔臂将胆甾醇连接到普鲁兰分子链上,对普鲁兰多糖进行疏水改性,获得不同取代度的胆甾醇基-普鲁兰(cholesterol-modified pullulan,CHSP)改性材料,并研究CHSP材料在水中的自组装性质。方法:利用1-乙基-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐(EDC)和4-二甲氨基吡啶(DMAP)催化琥珀酰胆甾醇(cholesterol succinate,CHS)与普鲁兰多糖反应,将琥珀酰胆甾醇接枝在普鲁兰分子链的羟基上,得到疏水改性的普鲁兰多糖衍生物。应用傅立叶红外光谱仪(Fourier transform infrared spectroscopy,FT-IR),核磁共振仪(proton nuclear magnetic resonance,1H-NMR)对产物进行表征。利用透析法制备自组装纳米球。通过透射电镜(transmission electron microscopy,TEM),动态激光粒度分析仪(dynamic laser lightscattering,DLS)表征了纳米粒的形态和粒径。以芘为荧光探针,通过荧光检测分析,测定CHSP的临界胶束浓度(critical... 【英文摘要】 Objective:To synthesize cholesterol-modified pullulan(CHSP) conjugates and to preparate self-assembled nanoparticles.Methods:The cholesterol-modified pullulan(CHSP) was prepared by the reaction of pullulan and cholesterol succinate(CHS) in DMSO,using EDC and DMAP as catalysts.The polymer structure was confirmed by the Fourier transform infrared spectroscopy(FT-IR) and proton nuclear magnetic resonance(1H-NMR).The self-assembled nanoparticles were analyzed by transmission electron microscopy(TEM),dynamic las...zh_CN
dc.description.sponsorship国家重大科学研究计划项目(2006CB933300);; 博士点基金(20060023050)zh_CN
dc.language.isozhzh_CN
dc.publisher中国医药科技出版社;中国医药集团总公司;中国药学会zh_CN
dc.subject普鲁兰zh_CN
dc.subject琥珀酰胆甾醇zh_CN
dc.subject自聚集纳米粒zh_CN
dc.subjectpullulanzh_CN
dc.subjectcholesterol succinatezh_CN
dc.subjectself-assembled nanoparticleszh_CN
dc.title胆甾醇基-普鲁兰多糖疏水改性材料的制备及其自组装性质的研究zh_CN
dc.title.alternativePreparation of self-assembled cholesterol modified pullulan nanopaticleszh_CN
dc.typeArticlezh_CN


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