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dc.contributor.advisor许华曦
dc.contributor.author姜尚彤
dc.date.accessioned2016-01-13T08:58:43Z
dc.date.available2016-01-13T08:58:43Z
dc.date.issued2014-02-27 11:26:33.0
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/78724
dc.description.abstract阿尔茨海默症(Alzheimer’sdisease,AD)病人的显著病变之一是大脑中的β分泌酶BACE1切割淀粉样前体蛋白APP产生的Aβ所形成的具有神经毒性的淀粉样斑。此外BACE1也参与精神分裂症(Schizophrenia)的发病。由于BACE1活性及水平受到细胞内多种蛋白的调控,因此寻找调控BACE1的蛋白在AD和精神分裂症的治疗中具有重要意义。 我们通过酵母双杂交的实验方法筛选出一种可能与BACE1发生相互作用的蛋白—人类M1Muscarinic乙酰胆碱受体(M1MuscarinicAcetylcholineReceptor,M1mAChR,以下简称M1受体),并在酵母中通过β-g...
dc.description.abstractOne pronounced pathology of Alzheimer’s disease (AD) is the accumulation of neurotoxic peptide -amyloid (A), which is the resultant product of APP upon sequential cleavage by -secretase (BACE1) and -secretase. The protein level and activity of BACE1 have been found upregulated in sporadic AD, suggesting that a dysregulation of BACE1 may trigger AD pathogenesis. Moreover, BACE1 is found to be invo...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=40395&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=43425
dc.subject阿尔茨海默症
dc.subjectβ分泌酶BACE1
dc.subjectMuscarinic M1乙酰胆碱受体
dc.subject精神分裂症
dc.subjectAlzheimer’s disease
dc.subjectBACE1
dc.subjectMuscarinic M1
dc.subjectSchizophrenia
dc.title人类M1 Muscarinic乙酰胆碱受体调控BACE1水平的新机制
dc.title.alternativeA new mechanism by which M1 A new mechanism by which M1 mechanism by which M1 Muscarinic Acetylcholine Receptor regulates BACE1 level
dc.typethesis
dc.date.replied2013-09-04
dc.description.note学位:理学博士
dc.description.note院系专业:生物医学研究院_化学生物学
dc.description.note学号:30520100153940


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