Show simple item record

dc.contributor.authorHou, Zhenqingzh_CN
dc.contributor.authorLin, Chenghongzh_CN
dc.contributor.authorZhang, Qiqingzh_CN
dc.contributor.author张其清zh_CN
dc.contributor.authorTang, Xiaolongzh_CN
dc.contributor.authorWang, Yuqianzh_CN
dc.date.accessioned2013-12-12T02:51:18Z
dc.date.available2013-12-12T02:51:18Z
dc.date.issued2009zh_CN
dc.identifier.citation2009 3rd International Conference on Bioinformatic1082-1085zh_CN
dc.identifier.issn978-1-4244-2901-1zh_CN
dc.identifier.otherWOS:000286342800267zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/71455
dc.description.abstractThe ultrasound contrast agent based on a poly lactic acid (PLA) was prepared by combining an ultrasound method and a Shirasu Porous Glass (SPG) membrane emulsification technique. An aqueous phase containing ammonium bicarbonate was used as the internal water phase (WO, and PLA and Span 80 were dissolved in a solvent of dichloromethane (DCM), which was used as the oil phase (0). These two solutions were probe sonicated to form a W(1)/O primary emulstion. The primary emulsion was permeated through the uniform pores (1.1 mu m) of an SPG membrane into the external water phase (W(2)) by the pressure of nitrogen gas to form the uiniform W(1)/O/W(2) droplets. After DCM was evaporated, the hardened PLA microcapsules were further formulated into a lyophilized powder containing decafluorobutane gas. SEM image demonstrated that the PLA microcapsules were sphere-shaped and internally hollow with an average diameter ranging from 1.99 to 3.58 mu m. In vitro, the PLA contrast agents showed high acoustic enhancement properties, the enhancement increased nonlinearly with dose, and the minimal loss (less than 5 dB) of signal was observed over 20 min of analysis at 37 degrees C, the maximum acoustic enhancement was 45 dB, which significantly higher (p<0.01) compared to a value of 28 dB for those prepared by a conventional solvent evaporation method. In conclusion, the hollow PLA microcapsules prepared by the novel method have the characteristics desirable for an intravenously administered ultrasound contrast agents.zh_CN
dc.language.isoen_USzh_CN
dc.subjectSPG membrane emulsificationzh_CN
dc.subjectPoly(lactide)zh_CN
dc.subjectUltrasound contrast agentzh_CN
dc.titlePreparation and characterization of PLA ultrasound contrast agents by combining an ultrasound method and a Shirasu Porous Glass (SPG) membrane emulsification techniquezh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record