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dc.contributor.authorChen, H. L.zh_CN
dc.contributor.authorYang, W. Z.zh_CN
dc.contributor.authorChen, H.zh_CN
dc.contributor.authorLiu, L. R.zh_CN
dc.contributor.authorGao, F. P.zh_CN
dc.contributor.authorYang, X. D.zh_CN
dc.contributor.authorJiang, Q.zh_CN
dc.contributor.authorZhang, Q. Q.zh_CN
dc.contributor.authorWang, Y. S.zh_CN
dc.contributor.author张其清zh_CN
dc.date.accessioned2013-12-12T02:51:17Z
dc.date.available2013-12-12T02:51:17Z
dc.date.issued2009-10-15zh_CN
dc.identifier.citationColloids and Surfaces B-Biointerfaces, 2009,73(2):212-218zh_CN
dc.identifier.issn0927-7765zh_CN
dc.identifier.otherISI:000269598900008zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/71445
dc.descriptionThe National Key Scientific Program [2006CB933300]zh_CN
dc.description.abstractThe purpose of this research was to develop polylactic-co-glycolic acid (PLGA) nanospheres surface modified with chitosan (CS). Mitoxantrone- (MTO-) loaded PLGA nanospheres were prepared by a solvent evaporation technique. The PLGA nanospheres surface was modified with CS by two strategies (adsorption and covalent binding). PLGA nanospheres of 248.4 +/- 21.0 nm in diameter characterized by the laser light scattering technique, scanning electron microscopy (SEM) are spherical and its drug encapsulation efficiency is 84.1 +/- 3.4%. Zeta potential of unmodified nanospheres was measured to be negative -21.21 +/- 2.13 mV. The positive zeta potential of modified nanospheres reveals the presence of CS on the surface of the modified nanospheres. Modified nanospheres were characterized for surface chemistry by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FT-IR). FT-IR spectra exhibited peaks at 3420 cm(-1) and 1570 cm(-1), XPS spectra shows the N 1s (atomic orbital is of nitrogen) region of the surface of the nanospheres, corresponding to the primary amide of CS. In vitro drug release demonstrated that CS-modified nanospheres have many advantages such as prolonged drug release property and decreased the burst release over the unmodified nanospheres, and the modified nanospheres by covalent binding method could achieve the release kinetics of a relatively constant release. These data demonstrate high potential of CS-modified PLGA nanospheres for the anticancer drug carrier. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.colsurfb.2009.05.020zh_CN
dc.subjectNANOPARTICLESzh_CN
dc.subjectDELIVERYzh_CN
dc.subjectMICROPARTICLESzh_CN
dc.subjectADSORPTIONzh_CN
dc.subjectCANCERzh_CN
dc.subjectCELLSzh_CN
dc.subjectMICROSPHERESzh_CN
dc.subjectFORMULATIONzh_CN
dc.subjectPARTICLESzh_CN
dc.subjectCARRIERSzh_CN
dc.titleSurface modification of Mitoxantrone-loaded PLGA nanospheres with chitosanzh_CN
dc.typeArticlezh_CN


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