Show simple item record

dc.contributor.authorYang, X. D.zh_CN
dc.contributor.authorZhang, Q. Q.zh_CN
dc.contributor.authorWang, Y. S.zh_CN
dc.contributor.authorChen, H.zh_CN
dc.contributor.authorZhang, H. Z.zh_CN
dc.contributor.authorGao, F. P.zh_CN
dc.contributor.authorLiu, L. R.zh_CN
dc.contributor.author张其清zh_CN
dc.date.accessioned2013-12-12T02:51:17Z
dc.date.available2013-12-12T02:51:17Z
dc.date.issued2008-02-15zh_CN
dc.identifier.citationColloids and Surfaces B-Biointerfaces, 2008,61(2):125-131zh_CN
dc.identifier.issn0927-7765zh_CN
dc.identifier.otherISI:000252919500001zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/71442
dc.description.abstractMethoxy poly(ethylene glycol)-grafted-chitosan (mPEG-g-CS) conjugates were synthesized by formaldehyde linking method and characterized by Fourier transform infrared (FT-IR) and proton nuclear magnetic resonance (H-1-NMR). The degree of substitution (DS) of methoxy poly (ethylene glycol) (mPEG) in the mPEG-g-CS molecules determined by H-1-NMR ranged from 19% to 42%. The critical aggregation concentration (CAC) was determined by fluorescence spectroscopy using pyrene as fluorescence probe and its value was 0.07 mg/mL in water. mPEG-g-CS formed monodisperse self-aggregated nanoparticles with a roughly spherical shape and a mean diameter of 261.9 nm were prepared by the dialysis method. mPEG-g-CS self-aggregated nanoparticles were used as carriers of poorly water-soluble anticancer drug methotrexate (MTX). MTX was physically entrapped inside mPEG-g-CS self-aggregated nanoparticles by dialysis method and the characteristics of MTX-loaded mPEG-g-CS self-aggregated nanoparticles were analyzed using dynamic laser light scattering (DLLS), transmission electron microscopy (TEM). Moreover, in vitro release behavior of MTX was also investigated and the results showed that MTX was continuously released more than 50% in 48 h. (c) 2007 Elsevier B.V. All rights reserved.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.colsurfb.2007.07.012zh_CN
dc.subjectACID-MODIFIED CHITOSANzh_CN
dc.subjectPEG-GRAFTED CHITOSANzh_CN
dc.subjectAQUEOUS-SOLUTIONzh_CN
dc.subjectPOLYMERIC MICELLESzh_CN
dc.subjectLINKED CHITOSANzh_CN
dc.subjectPACLITAXELzh_CN
dc.subjectDELIVERYzh_CN
dc.subjectDERIVATIVESzh_CN
dc.subjectCARRIERSzh_CN
dc.subjectSYSTEMzh_CN
dc.titleSelf-aggregated nanoparticles from methoxy poly(ethylene glycol)-modified chitosan: Synthesis; characterization; aggregation and methotrexate release in vitrozh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record