Fabrication of Cluster/Shell Fe3O4/Au Nanoparticles and Application in Protein Detection via a SERS Method
Xu, W. L.
Shi, Y. F.
Zhong, L. B.
Zhang, Q. Q.
- 医学院－已发表论文 
We have successfully synthesized cluster/shell Fe3O4/Au nanoparticles using a pH-sensitive polyethyleneimine (PEI) linker. We propose that PEI binds gold seeds, prevents the formation of large aggregates, and changes the spatial structure in an alkaline environment to bundle several Fe3O4/Au-seed nanoparticles together through a bridging flocculation function, thereby producing cluster/shell Fe3O4/Au nanoparticles. We successfully applied the synthesized cluster/shell Fe3O4/Au nanoparticles to free-PSA detection via a surface-enhanced Raman scattering (SERS) method, presenting a convenient way for preconcentrating, purifying, and detecting target proteins in complex biosamples. The synthesis strategy demonstrated here can be extended to the fabrication of a wide range of cluster/shell nanocomposites for biomedical applications.
DescriptionNatural Science Foundation of China ; Natural Science Foundation of Fujian Province of China [2010J01046]
CitationJournal of Physical Chemistry C, 2010,114(46):19607-19613
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