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dc.contributor.authorLiu, M.zh_CN
dc.contributor.authorZhou, Z. M.zh_CN
dc.contributor.authorWang, X. F.zh_CN
dc.contributor.authorXu, J.zh_CN
dc.contributor.authorYang, K.zh_CN
dc.contributor.authorCui, Q.zh_CN
dc.contributor.authorChen, X.zh_CN
dc.contributor.authorCao, M. Y.zh_CN
dc.contributor.authorWeng, J.zh_CN
dc.contributor.authorZhang, Q. Q.zh_CN
dc.contributor.author张其清zh_CN
dc.date.accessioned2013-12-12T02:51:14Z
dc.date.available2013-12-12T02:51:14Z
dc.date.issued2007-09-10zh_CN
dc.identifier.citationPolymer, 2007,48(19):5767-5779zh_CN
dc.identifier.issn0032-3861zh_CN
dc.identifier.otherISI:000250161000037zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/71389
dc.description.abstractIn this work, we show that simple dialysis of a poly(DL-lactic acid) (PLA) solution against water resulted in the spontaneous formation of PLA spheres. We observed initial formation of particles with irregular shape and large size, which then were disrupted into uniform and smooth nanospheres. Further, the formation process of PLA spheres was also investigated by dynamic light scattering technique (DLS) in situ. Based on these experimental results, it was proposed that the PLA spheres were formed in three steps: (1) aggregation - individual PLA chains got aggregated with each other in solution; (2) formation and disruption of PLA particles; (3) solidification of PLA spheres. In addition, the size of the spheres could be well controlled by the preparation conditions such as the speed of dialysis, initial solvent, initial water content and polymer concentration. The ease with which these spheres could be fabricated and the ability to control the size of spheres should facilitate investigations of their scope for drug delivery. (C) 2007 Elsevier Ltd. All rights reserved.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.polymer.2007.07.053zh_CN
dc.subjectPOLY(DL-LACTIDE-CO-GLYCOLIDE) NANOPARTICLESzh_CN
dc.subjectCONTROLLED-RELEASEzh_CN
dc.subjectPARTICLE-SIZEzh_CN
dc.subjectIN-VITROzh_CN
dc.subjectMICROSPHERESzh_CN
dc.subjectDELIVERYzh_CN
dc.subjectSURFACTANTzh_CN
dc.subjectCARRIERSzh_CN
dc.subjectPOLYMERzh_CN
dc.subjectACID)zh_CN
dc.titleFormation of poly(L,D-lactide) spheres with controlled size by direct dialysiszh_CN
dc.typeArticlezh_CN


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