Synthesis, characterization and antitumor activity of benzaldehyde nitrogen mustard picolinoyl hydrazone complexes
- 物理技术－已发表论文 
Cu-II, Ni-II, Co-II, Zn-II and Cd-II complexes of picolin-amido-4-bis(2-chloroethyl)aminobenzaldimine (PBAB) have been synthesized and characterized by elemental analysis, conductivity, i.r. u.v.-vis. and e.p.r. spectra. The results suggest a square planar structure for the Cu-II complex, a tetrahedral geometry for the Zn-II and Cd-II complexes and an octahedral structure for the Co-II and Ni-II complexes. The complexes have been screened for antitumor activity against SMMC-7721 human liver cancer cell line; all of them exhibit biological activity at high concentrations for the cell line studied and a synergic effect between Cu-II and PBAB is evident.