Show simple item record

dc.contributor.authorChen, H. F.zh_CN
dc.contributor.authorOu, W. C.zh_CN
dc.contributor.authorWang, G. H.zh_CN
dc.contributor.authorWang, N. L.zh_CN
dc.contributor.authorZhang, L. N.zh_CN
dc.contributor.authorYao, X. S.zh_CN
dc.contributor.author陈海峰zh_CN
dc.date.accessioned2013-12-12T02:25:47Z
dc.date.available2013-12-12T02:25:47Z
dc.date.issued2010-07zh_CN
dc.identifier.citationMolecules, 2010,15(7):4589-4598zh_CN
dc.identifier.issn1420-3049zh_CN
dc.identifier.otherISI:000280340900007zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/66050
dc.identifier.urihttp://dx.doi.org/10.3390/molecules 15074589
dc.description.abstractThree new compounds were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated from their spectral data as (25R)-26-O-beta-D-glucopyranosyl-5 alpha-furostane-3 beta, 12 beta,22,26-tetraol-3-O-beta-D-glucopyranosyl (1 -> 2) [beta-D-glucopyranosyl (1 -> 3)]-beta-D-glucopyranosyl (1 -> 4)-beta-D-galactopyranoside (1), (25R)-26-O-beta-D-glucopyranosyl-5 alpha-furostane-3 beta, 12 alpha,22,26-tetraol-3-O-beta-D-gluco-pyranosyl (1 -> 2) [beta-D-glucopyranosyl (1 -> 3)]-beta-D-glucopyranosyl (1 -> 4)-beta-D-galacto-pyranoside (2) and (25R)-26-O-beta-D-glucopyranosyl-5 beta-furostane-3 beta, 12 alpha,22,26-tetraol-3-O-beta-D-glucopyranosyl (1 -> 2)-beta-D-galactopyranoside (3), respectively. The inhibition effect of all compounds on CD40 ligand (CD40L) expression on the membrane of activated platelets stimulated by ADP was tested. Compounds 1 and 2 exhibited significant inhibitory activities in a dose dependent manner (P < 0.05), suggesting their potential application as CD40L inhibitors.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.3390/molecules15074589zh_CN
dc.subjectFUROSTANOL SAPONINSzh_CN
dc.subjectALLIUM MACROSTEMONzh_CN
dc.subjectT-CELLSzh_CN
dc.subjectLIGANDzh_CN
dc.subjectTRIGGERSzh_CN
dc.titleNew Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Plateletszh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record