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dc.contributor.authorZhang, Y. W.zh_CN
dc.contributor.authorLuo, H. R.zh_CN
dc.contributor.authorRyder, O. A.zh_CN
dc.contributor.authorZhang, Y. P.zh_CN
dc.contributor.author张云武zh_CN
dc.date.accessioned2013-12-12T02:25:43Z
dc.date.available2013-12-12T02:25:43Z
dc.date.issued2004zh_CN
dc.identifier.citationGene,338(1):47-54zh_CN
dc.identifier.issn0378-1119zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/66014
dc.description.abstractThe upstream regulatory region of the human thymidylate synthase gene (thymidylate synthase enhancer region, TSER) is length polymorphic, attributable to variable numbers of tandemly repeated copies of a 28-bp fragment. It has been found that TSER length polymorphism is correlated to malignancy risk. To further our understanding of the origin and evolution of TSER, this region was investigated among different primates, including hominoids, two subfamilies of the Old World monkeys (OWMs): colobines and cercopithecines, and two species of the New World monkeys (NWMs). In addition to humans, our results show that length polymorphism in TSER is also present in some primate populations, although it appears that this region is length monomorphic in many other primates. We identified three unique repeat motifs in TSER and defined them as R1, R2, and R3, respectively, starting from the 3' end. The same repeat motifs from different species are more similar to each other than different repeat motifs within same species are. Such a paraphyletic pattern suggests that divergence of the three repeat motifs predated divergence of the OWMs/hominoids and the NWMs. The most recent common ancestor (MRCA) of hominoids and the OWMs probably possessed triple repeats but now double and triple repeats are two dominant types in hominoids and the OWMs. In addition, our results show that each of the three repeat motifs may be lost independently. We have also found clues that recombination was involved in formation of tandem repeat polymorphism in TSER. (C) 2004 Elsevier B.V. All rights reserved.zh_CN
dc.language.isoen_USzh_CN
dc.subjectrepeat motifzh_CN
dc.subjectlength polymorphismzh_CN
dc.subjectpopulationzh_CN
dc.subjectrecombinationzh_CN
dc.titleEvolution of the tandem repeats in thymidylate synthase enhancer region (TSER) in primateszh_CN
dc.typeArticlezh_CN


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