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dc.contributor.authorLi, H.zh_CN
dc.contributor.authorZhang, Y.zh_CN
dc.contributor.authorZhang, Y. P.zh_CN
dc.contributor.authorFu, Y. X.zh_CN
dc.contributor.author张云武zh_CN
dc.date.accessioned2013-12-12T02:25:41Z
dc.date.available2013-12-12T02:25:41Z
dc.date.issued2003zh_CN
dc.identifier.citationGenetics,163(3):1147-51zh_CN
dc.identifier.issn0016-6731zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/66002
dc.description.abstractThe polymorphism of a gene or a locus is studied with increasing frequency by multiple laboratories or the same group at different times. Such practice results in polymorphism being revealed by different samples at different regions of the locus. Tests of neutrality have been widely conducted for polymorphism data but commonly used statistical tests cannot be applied directly to such data. This article provides a procedure to conduct a neutrality test and details are given for two commonly used tests. Applying the two new tests to the chemokine-receptor gene (CCR5) in humans, we found that the hypothesis that all mutations are selectively neutral cannot explain the observed pattern of DNA polymorphism.zh_CN
dc.language.isoen_USzh_CN
dc.subjectSEGREGATING SITESzh_CN
dc.subjectMUTATIONSzh_CN
dc.subjectSEQUENCESzh_CN
dc.titleNeutrality tests using DNA polymorphism from multiple sampleszh_CN
dc.typeArticlezh_CN


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