Neutrality tests using DNA polymorphism from multiple samples

dc.contributor.author	Li, H.	zh_CN
dc.contributor.author	Zhang, Y.	zh_CN
dc.contributor.author	Zhang, Y. P.	zh_CN
dc.contributor.author	Fu, Y. X.	zh_CN
dc.contributor.author	张云武	zh_CN
dc.date.accessioned	2013-12-12T02:25:41Z
dc.date.available	2013-12-12T02:25:41Z
dc.date.issued	2003	zh_CN
dc.identifier.citation	Genetics,163(3):1147-51	zh_CN
dc.identifier.issn	0016-6731	zh_CN
dc.identifier.uri	https://dspace.xmu.edu.cn/handle/2288/66002
dc.description.abstract	The polymorphism of a gene or a locus is studied with increasing frequency by multiple laboratories or the same group at different times. Such practice results in polymorphism being revealed by different samples at different regions of the locus. Tests of neutrality have been widely conducted for polymorphism data but commonly used statistical tests cannot be applied directly to such data. This article provides a procedure to conduct a neutrality test and details are given for two commonly used tests. Applying the two new tests to the chemokine-receptor gene (CCR5) in humans, we found that the hypothesis that all mutations are selectively neutral cannot explain the observed pattern of DNA polymorphism.	zh_CN
dc.language.iso	en_US	zh_CN
dc.subject	SEGREGATING SITES	zh_CN
dc.subject	MUTATIONS	zh_CN
dc.subject	SEQUENCES	zh_CN
dc.title	Neutrality tests using DNA polymorphism from multiple samples	zh_CN
dc.type	Article	zh_CN