Show simple item record

dc.contributor.authorLu, Zzh_CN
dc.contributor.authorLam, KSzh_CN
dc.contributor.authorWang, Nzh_CN
dc.contributor.authorXu, Xzh_CN
dc.contributor.authorCortes, Mzh_CN
dc.contributor.authorAndersen, Bzh_CN
dc.contributor.author吕忠显zh_CN
dc.date.accessioned2013-12-12T02:25:38Z
dc.date.available2013-12-12T02:25:38Z
dc.date.issued2006zh_CN
dc.identifier.citationOncogene,25(20):2920-2930zh_CN
dc.identifier.issn0950-9232zh_CN
dc.identifier.otherWOS:000237448200010zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/65986
dc.description.abstractLIM- only protein 4 ( LMO4) plays critical roles in mammalian development, and has been proposed to play roles in epithelial oncogenesis, including breast cancer. As LMO4 is highly expressed in the epithelial compartments at locations of active mesenchymal - epithelial interactions, we reasoned that LMO4 might act by modulating signaling pathways involved in mesenchymal - epithelial signaling. One such candidate signal is the transforming growth factor- beta ( TGF beta) cytokine pathway, which plays important roles both in development and cancer. We show here that the transcriptional response to TGFb in epithelial cells is sensitive to LMO4 levels; both up- and downregulation of LMO4 can enhance TGF beta signaling as assessed by a TGF beta- responsive reporter gene. Furthermore, LMO4 can interact with the MH1 and linker domains of receptor- mediated Smad proteins, and associate with the endogenous TGF beta- responsive Plasminogen Activator Inhibitor- 1 gene promoter in a TGF beta- dependent manner, suggesting that such interactions may mediate the effects of LMO4 on TGFb signaling. When introduced into mammary epithelial cells, LMO4 potentiated the growth- inhibitory effects of TGF beta in those cells. These results de. ne a new function for LMO4 as a coactivator in TGFb signaling, and provide a potential novel mechanism for LMO4- mediated regulation in development and oncogenesis.zh_CN
dc.language.isoen_USzh_CN
dc.subjectLMO4zh_CN
dc.subjecttransforming growth factor-betazh_CN
dc.subjectSmadszh_CN
dc.subjectmammary gland epithelial cellszh_CN
dc.subjectcellular proliferationzh_CN
dc.titleLMO4 can interact with Smad proteins and modulate transforming growth factor-beta signaling in epithelial cellszh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record